Oncologists use drugs that limit a tumour's blood supply to prevent its growth. Although the initial effects of these drugs are beneficial to patients, new data suggest that their long-term effects warrant further study.
References
Pàez-Ribes, M. et al. Cancer Cell 15, 220–231 (2009).
Ebos, J. M. L. et al. Cancer Cell 15, 232–239 (2009).
Ellis, L. M. & Hicklin, D. J. Nature Rev. Cancer 8, 579–591 (2008).
Ferrara, N. et al. Nature 380, 439–442 (1996).
Lee, S. et al. Cell 130, 691–703 (2007).
Ebos, J. M. L. et al. Proc. Natl Acad. Sci. USA 104, 17069–17074 (2007).
Du, R. et al. Cancer Cell 13, 206–220 (2008).
Grothey, A. et al. J. Clin. Oncol. 26, 5326–5334 (2008).
Escudier, B. et al. N. Engl. J. Med. 356, 125–134 (2007).
Llovet, J. M. et al. N. Engl. J. Med. 359, 378–390 (2008).
Vredenburgh, J. J. et al. J. Clin. Oncol. 25, 4722–4729 (2007).
Kopetz, S. et al. Proc. 2009 Gastrointest. Cancers Symp. Abstr. 292 (Am. Soc. Clin. Oncol., 2009).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ellis, L., Reardon, D. The nuances of therapy. Nature 458, 291–292 (2009). https://doi.org/10.1038/458290a
Published:
Issue Date:
DOI: https://doi.org/10.1038/458290a
- Springer Nature Limited
This article is cited by
-
Targeting the extracellular matrix for immunomodulation: applications in drug delivery and cell therapies
Drug Delivery and Translational Research (2021)
-
Consensus guidelines for the use and interpretation of angiogenesis assays
Angiogenesis (2018)
-
Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions
Angiogenesis (2014)
-
Innovations in studying in vivo cell behavior and pharmacology in complex tissues – microvascular endothelial cells in the spotlight
Cell and Tissue Research (2013)
-
Betulinic Acid Induces Bax/Bak-Independent Cytochrome c Release in Human Nasopharyngeal Carcinoma Cells
Molecules and Cells (2012)