How can we investigate a disease affecting neurons, which cannot be isolated from patients for analysis? As the study of one neurological disorder shows, a first step might be to make patient-specific neurons.
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References
Ebert, A. D. et al. Nature 457, 277–280 (2009).
Schrank, B. et al. Proc. Natl Acad. Sci. USA 94, 9920–9925 (1997).
Wang, J. & Dreyfuss, G. J. Biol. Chem. 276, 9599–9605 (2001).
Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).
Hanna, J. et al. Science 318, 1920–1923 (2007).
Dimos, J. T. et al. Science 321, 1218–1221 (2008).
Lobsiger, C. S. & Cleveland, D. W. Nature Neurosci. 10, 1355–1360 (2007).
Di Giorgio, F. P., Boulting, G. L., Bobrowicz, S. & Eggan, K. C. Cell Stem Cell 3, 637–648 (2008).
Nishimune, H., Sanes, J. R. & Carlson, S. S. Nature 432, 580–587 (2004).
Jablonka, S., Beck, M., Lechner, B. D., Mayer, C. & Sendtner, M. J. Cell Biol. 179, 139–149 (2007).
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Sendtner, M. Tailor-made diseased neurons. Nature 457, 269–270 (2009). https://doi.org/10.1038/457269a
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DOI: https://doi.org/10.1038/457269a
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