More than 20 million people worldwide have Alzheimer's disease, yet its causes remain mostly uncertain. Fresh findings provide molecular clues, linking this disease to another neurodegenerative disorder.
References
Lesné, S. et al. Nature 440, 352–357 (2006).
Cheng, I. H. et al. J. Biol. Chem. 282, 23818–23828 (2007).
Shankar, G. M. et al. J. Neurosci. 27, 2866–2875 (2007).
Laurén, J., Gimbel, D. A., Nygaard, H. B., Gilbert, J. W. & Strittmatter, S. M. Nature 457, 1128–1132 (2009).
Aguzzi, A., Baumann, F. & Bremer, J. Annu. Rev. Neurosci. 31, 439–477 (2008).
Prusiner, S. B. Annu. Rev. Med. 38, 381–398 (1987).
Verdier, Y., Zarándi, M. & Penke, B. J. Pept. Sci. 10, 229–248 (2004).
Sturchler, E., Galichet, A., Weibel, M., Leclerc, E. & Heizmann, C. W. J. Neurosci. 28, 5149–5158 (2008).
Origlia, N. et al. J. Neurosci. 28, 3521–3530 (2008).
Vincent, B., Cisse, M. A., Sunyach, C., Guillot-Sestier, M.-V. & Checler, F. Curr. Alzheimer Res. 5, 202–211 (2008).
Shankar, G. M. et al. Nature Med. 14, 837–842 (2008).
Roberson, E. D. et al. Science 316, 750–754 (2007).
Wang, X.-F. et al. Mol. Cell. Biochem. 310, 49–55 (2008).
Mouillet-Richard, S. et al. Science 289, 1925–1928 (2000).
Chin, J. et al. J. Neurosci. 25, 9694–9703 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cisse, M., Mucke, L. A prion protein connection. Nature 457, 1090–1091 (2009). https://doi.org/10.1038/4571090a
Published:
Issue Date:
DOI: https://doi.org/10.1038/4571090a
- Springer Nature Limited
This article is cited by
-
Copper Binding Regulates Cellular Prion Protein Function
Molecular Neurobiology (2019)
-
Stability analysis of a steady state of a model describing Alzheimer’s disease and interactions with prion proteins
Journal of Mathematical Biology (2019)
-
The 37kDa/67kDa Laminin Receptor acts as a receptor for Aβ42 internalization
Scientific Reports (2014)
-
Alzheimer’s disease: analysis of a mathematical model incorporating the role of prions
Journal of Mathematical Biology (2014)
-
PrP106-126 and Aβ1-42 Peptides Induce BV-2 Microglia Chemotaxis and Proliferation
Journal of Molecular Neuroscience (2014)