Small-scale interactions of substrates with an enzyme's active site — over distances smaller than the length of a chemical bond — can make big differences to the enzyme's catalytic efficiency.
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Kirby, A., Hollfelder, F. Enzymes under the nanoscope. Nature 456, 45–47 (2008). https://doi.org/10.1038/456045a
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DOI: https://doi.org/10.1038/456045a
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