When a potentially dangerous cell can't be repaired, it must be either stopped or killed. Premature senescence of cancerous cells is one such 'stop' mechanism, in which immune mediators play an unexpected part.
References
Finkel, T., Serrano, M. & Blasco, M. A. Nature 448, 767–774 (2007).
Kuilman, T. et al. Cell 133, 1019–1031 (2008).
Acosta, J. C. et al. Cell 133, 1006–1018 (2008).
Campisi, J. & d'Adda di Fagagna, F. Nature Rev. Mol. Cell Biol. 8, 729–740 (2007).
Chien, Y. & Lowe, S. W. Cell 132, 339–341 (2008).
Michaloglou, C. et al. Nature 436, 720–724 (2005).
Mason, D. X., Jackson, T. J. & Lin, A. W. Oncogene 23, 9238–9246 (2004).
Schnabl, B., Purbeck, C. A., Choi, Y. H., Hagedorn, C. H. & Brenner, D. Hepatology 37, 653–664 (2003).
Sebastian, T., Malik, R., Thomas, S., Sage, J. & Johnson, P. F. EMBO J. 24, 3301–3312 (2005).
Wajapeyee, N., Serra, R. W., Zhu, X., Mahalingam, M. & Green, M. R. Cell 132, 363–374 (2008).
Denoyelle, C. et al. Nature Cell Biol. 8, 1053–1063 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Soengas, M. Ins and outs of tumour control. Nature 454, 586–587 (2008). https://doi.org/10.1038/454586a
Published:
Issue Date:
DOI: https://doi.org/10.1038/454586a
- Springer Nature Limited
This article is cited by
-
Hallmarks for senescence in carcinogenesis: novel signaling players
Apoptosis (2009)