Skip to main content
Log in

History of science

Quinine steps back in time

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

Chemists have long memories. The claim, dating back to 1918, that a crucial step in a synthesis of quinine had been carried out has been validated experimentally, closing a chapter in this fascinating story.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Gin and tonics all round.
Figure 2: The formal synthesis of quinine.

References

  1. Woodward, R. B. & Doering, W. E. J. Am. Chem. Soc. 66, 849 (1944).

    Google Scholar 

  2. Woodward, R. B. & Doering, W. E. J. Am. Chem. Soc. 67, 860–874 (1945).

    Article  CAS  Google Scholar 

  3. Smith, A. C. & Williams, R. M. Angew. Chem. Int. Edn 47, 1736–1740 (2008).

    Article  CAS  Google Scholar 

  4. Rabe, P. & Kindler, K. Ber. Deutsch. Chem. Ges. 51, 466–467 (1918).

    Article  CAS  Google Scholar 

  5. Proštenik, M. & Prelog, V. Helv. Chim. Acta 26, 1965–1971 (1943).

    Article  Google Scholar 

  6. Stork, G. et al. J. Am. Chem. Soc. 123, 3239–3242 (2001).

    Article  CAS  Google Scholar 

  7. Rouhi, A. M. Chem. Eng. News 79 (7 May), 54–56 (2001).

    Article  Google Scholar 

  8. Seeman, J. I. Angew. Chem. Int. Edn 46, 1378–1413 (2007).

    Article  CAS  Google Scholar 

  9. Rabe, P. Justus Liebigs Ann. Chem. 492, 242–266 (1932).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ball, P. Quinine steps back in time. Nature 451, 1065–1066 (2008). https://doi.org/10.1038/4511065a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/4511065a

  • Springer Nature Limited

This article is cited by

Navigation