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Alzheimer's disease

A firm base for drug development

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Figure 1: Proposed mechanism by which the amyloid β (Aβ) peptide is generated through cleavage by the newly identified β-site APP-cleaving enzyme, BACE2,3,4,5.

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Authors and Affiliations

  1. Flanders Interuniversitary Institute for Biotechnology and K. U. Leuven, Leuven, B-3000, Belgium

    Bart De Strooper

  2. Bayer AG, Pharma Research CNS, Wuppertal, 42096, Germany

    Gerhard König

Authors
  1. Bart De Strooper
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  2. Gerhard König
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Correspondence to Bart De Strooper or Gerhard König.

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De Strooper, B., König, G. A firm base for drug development. Nature 402, 471–472 (1999). https://doi.org/10.1038/44973

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