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Structural biology

Unexpected opening

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Cell membranes contain channels that open to allow ions into cells. The structure of a sodium ion channel helps explain how it opens in response to protons, and settles a long-standing debate about its composition.

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Figure 1: Proposed mechanism for sodium-ion channel opening.

References

  1. Kellenberger, S. & Schild, L. Physiol. Rev. 82, 735–767 (2002).

    Article  CAS  Google Scholar 

  2. Jasti, J., Furukawa, H., Gonzales, E. B. & Gouaux, E. Nature 449, 316–322 (2007).

    Article  CAS  ADS  Google Scholar 

  3. Waldmann, R., Champigny, G., Bassilana, F., Heurteaux, C. & Lazdunski, M. Nature 386, 173–177 (1997).

    Article  CAS  ADS  Google Scholar 

  4. Chelur, D. S. et al. Nature 420, 669–673 (2002).

    Article  CAS  ADS  Google Scholar 

  5. Lingueglia, E., Champigny, G., Lazdunski, M. & Barbry, P. Nature 378, 730–733 (1995).

    Article  CAS  ADS  Google Scholar 

  6. Canessa, C. M. et al. Nature 367, 463–467 (1994).

    Article  CAS  ADS  Google Scholar 

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Canessa, C. Unexpected opening. Nature 449, 293–294 (2007). https://doi.org/10.1038/449293a

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