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Cancer

Broken genes in solid tumours

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Mutations that cause portions of two genes to fuse together and form a hybrid gene are frequent in blood-related cancers. New findings implicate one such fusion gene in the most common type of lung cancer.

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Figure 1: The EML4–ALK fusion protein and lung cancer.

References

  1. Parkin, D. M., Bray, F., Ferlay, J. & Pisani P. CA Cancer J. Clin. 55, 74–108 (2005).

    Article  Google Scholar 

  2. Soda, M. et al. Nature 448, 561–566 (2007).

    Article  ADS  CAS  Google Scholar 

  3. Sawyers, C. Nature 432, 294–297 (2004).

    Article  ADS  CAS  Google Scholar 

  4. Druker, B. J. et al. N. Engl. J. Med. 344, 1031–1037 (2001).

    Article  CAS  Google Scholar 

  5. de Klein, A. et al. Nature 300, 765–767 (1982).

    Article  ADS  CAS  Google Scholar 

  6. Morris, S. W. et al. Science 263, 1281–1284 (1994).

    Article  ADS  CAS  Google Scholar 

  7. Sharma, S. V., Bell, D. W., Settleman, J. & Haber D. A. Nature Rev. Cancer 7, 169–181 (2007).

    Article  CAS  Google Scholar 

  8. Lynch, T. J. et al. N. Engl. J. Med. 350, 2129–2139 (2004).

    Article  CAS  Google Scholar 

  9. Paez, J. G. et al. Science 304, 1497–1500 (2004).

    Article  ADS  CAS  Google Scholar 

  10. Pao, W. et al. Proc. Natl Acad. Sci. USA 101, 13306–13311 (2004).

    Article  ADS  CAS  Google Scholar 

  11. Tomlins, S. A. et al. Science 310, 644–648 (2005).

    Article  ADS  CAS  Google Scholar 

  12. Tomlins, S. A. et al. Nature 448, 595–599 (2007).

    Article  ADS  CAS  Google Scholar 

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Meyerson, M. Broken genes in solid tumours. Nature 448, 545–546 (2007). https://doi.org/10.1038/448545a

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