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Neurobiology

New order for thought disorders

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Can we really learn about complex human psychiatric disorders through genetic manipulations in mice? Yes, according to studies of how altering the gene encoding neuregulin 1 affects signalling in the mouse brain.

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Figure 1: Neuregulin's role in synaptic transmission.
Figure 2: An 'inverted-U model' of Nrg1 signalling.

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Authors and Affiliations

  1. Lorna W. Role is in the Department of Neurobiology and Behavior, and David A. Talmage is in the Department of Pharmacology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA. Lorna.Role@Stonybrook.edu,

    Lorna W. Role & David A. Talmage

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  1. Lorna W. Role
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  2. David A. Talmage
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Role, L., Talmage, D. New order for thought disorders. Nature 448, 263–265 (2007). https://doi.org/10.1038/448263a

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