The availability of short interfering RNAs (siRNAs) to silence gene expression has revolutionized research in molecular cell biology. But these synthetic siRNAs rely on cellular enzymes for their activity.
This is a preview of subscription content, log in via an institution to check access.
References
Weitzer, S. & Martinez, S. Nature 447, 222–226 (2007).
Pham, J. W. et al. Cell 117, 83–94 (2004).
Elbashir, S. M. et al. Nature 411, 494–498 (2001).
Elbashir, S. M., Lendeckel, W. & Tuschl, T. Genes Dev. 15, 188–200 (2001).
Caplen, N. J., Parrish, S., Imani, F., Fire, A. & Morgan, R. A. Proc. Natl Acad. Sci. USA 98, 9742–9747 (2001).
Nykanen, A., Haley, B. & Zamore, P. D. Cell 107, 309–321 (2001).
Pellino, J. L., Jaskiewicz, L., Filipowicz, W. & Sontheimer, E. J. RNA 11, 1719–1724 (2005).
Pham, J. W. & Sontheimer, E. J. J. Biol. Chem. 280, 39278–39283 (2005).
de Vries, H. et al. EMBO J. 19, 5895–5904 (2000).
Paushkin, S. V. et al. Cell 117, 311–321 (2004).
Trotta, C. R., Li, H. & Abelson, J. J. Biol. Chem. 273, 12685–12688 (1998).
Wickens, M. & Gonzalez, T. Science 306, 1299–1300 (2004).
Zillmann, M., Gorovsky, M. A. & Phizicky, E. M. Mol. Cell. Biol. 11, 5410–5416 (1991).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Trotta, C. The big catch. Nature 447, 156–157 (2007). https://doi.org/10.1038/447156a
Published:
Issue Date:
DOI: https://doi.org/10.1038/447156a
- Springer Nature Limited
This article is cited by
-
Classification, diagnosis and potential mechanisms in Pontocerebellar Hypoplasia
Orphanet Journal of Rare Diseases (2011)