Keratin proteins perform several functions in skin cells, including those of providing mechanical support and protection against injury. But it seems they also have a more active part to play in healing wounds.
References
Fuchs, E. & Cleveland, D. W. Science 279, 514–519 (1998).
Herrmann, H., Hesse, M., Reichenzeller, M., Aebi, U. & Magin, T. M. Int. Rev. Cytol. 223, 83–175 (2003).
Omary, M. B., Coulombe, P. A. & McLean, W. H. I. N. Engl. J. Med. 351, 2087–2100 (2004).
Kim, S., Wong, P. & Coulombe, P. A. Nature 441, 362–365 (2006).
Woolley, K. & Martin, P. BioEssays 22, 911–919 (2000).
DePianto, D. & Coulombe, P. A. Exp. Cell Res. 301, 68–76 (2004).
Hay, N. & Sonenberg, N. Genes Dev. 18, 1926–1945 (2004).
Dougherty, M. K. & Morrison, D. K. J. Cell Sci. 117, 1875–1884 (2004).
Ku, N. O., Michie, S., Resurreccion, E. Z., Broome, R. L. & Omary, M. B. Proc. Natl Acad. Sci. USA 99, 4373–4378 (2002).
Tzivion, G., Luo, Z. J. & Avruch, J. J. Biol. Chem. 275, 29772–29778 (2001).
Santaro, M. M., Gaudino, G. & Marchisio, P.C. Dev. Cell 5, 257–271 (2003).
Macdonald, N. et al. Mol. Cell 20, 199–211 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Omary, M., Ku, NO. Skin care by keratins. Nature 441, 296–297 (2006). https://doi.org/10.1038/441296a
Published:
Issue Date:
DOI: https://doi.org/10.1038/441296a
- Springer Nature Limited