For a long time it was thought that there are only two types of T helper cell. But it is becoming clear that there may be other lineages that influence inflammatory responses in certain circumstances.
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References
Mangan, P. R. et al. Nature 441, 231–234 (2006).
Bettelli, E. et al. Nature 441, 235–238 (2006).
Langowski, J. L. et al. doi:10.1038/nature04808 (2006).
Dong, C. Nature Rev. Immunol. 6, 329–333 (2006).
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M. & Stockinger, B. Immunity 24, 179–189 (2006).
O'Shea, J. J., Ma, A. & Lipsky, P. Nature Rev. Immunol. 2, 37–45 (2002).
Fallon, P. G. et al. J. Exp. Med. 203, 1105–1116 (2006).
Owyang, A. M. et al. J. Exp. Med. 203, 843–849 (2006).
Chen, Z. et al. Proc. Natl Acad. Sci. USA (in the press).
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Tato, C., O'Shea, J. What does it mean to be just 17?. Nature 441, 166–167 (2006). https://doi.org/10.1038/441166a
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DOI: https://doi.org/10.1038/441166a
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