Abnormal protein clumps of many varieties build up in the brains of individuals with Alzheimer's disease. But which types actually cause memory deficits? The behaviour of model mice might help to find out.
This is a preview of subscription content, log in via an institution to check access.
References
Hebert, L., Scherr, P., Bienias, J., Bennett, D. & Evans, D. Arch. Neurol. 60, 1119–1122 (2003).
Lesne, S. et al. Nature 440, 352–357 (2006).
Tanzi, R. & Bertram, L. Cell 120, 545–555 (2005).
Walsh, D. M. & Selkoe, D. J. Neuron 44, 181–193 (2004).
Kobayashi, D. T. & Chen, K. S. Genes Brain Behav. 4, 173–196 (2005).
Klein, W. L., Krafft, G. A. & Finch, C. E. Trends Neurosci. 24, 219–224 (2001).
Palop, J. J. et al. J. Neurosci. 25, 9686–9703 (2005).
Georganopoulou, D. G. et al. Proc. Natl Acad. Sci. USA 102, 2273–2276 (2005).
Snyder, E. M. et al. Nature Neurosci. 8, 1051–1058 (2005).
Morris, R. G. M., Anderson, E., Lynch, G. S. & Baudry, M. S. Nature 319, 774–776 (1986).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Morris, R., Mucke, L. A needle from the haystack. Nature 440, 284–285 (2006). https://doi.org/10.1038/440284a
Published:
Issue Date:
DOI: https://doi.org/10.1038/440284a
- Springer Nature Limited
This article is cited by
-
Are microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer’s Disease?
Molecular Neurobiology (2016)