The selective production of a particular mirror-image form of a molecule is immensely important to organic synthesis. But techniques to find the right catalysts have traditionally been protracted and fiddly. Help is at hand.
References
Stinson, S. C. Chem. Eng. News 79, 79–97 (2001).
Reetz, M. T. & Li, X. G. Angew. Chem. Int. Edn 44, 2959–2962 (2005).
Hoen, R. et al. Angew. Chem. Int. Edn 44, 4209–4212 (2005).
Vogl, E. M., Gröger, H. & Shibasaki, M. Angew. Chem. Int. Edn 38, 1570–1577 (1999).
Walsh, P. J., Lurain, A. E. & Balsells, J. Chem. Rev. 103, 3297–3344 (2003).
Walsh, P. J., Balsells, J., Betancort, J. M. & Gama, G. J. J. Am. Chem. Soc. 122, 1802–1803 (2000).
Costa, A. M., Jimeno, C., Gavenonis, J., Carroll, P. J. & Walsh, P. J. J. Am. Chem. Soc. 124, 6929–6941 (2002).
Lurain, A. E., Carroll, P. J. & Walsh, P. J. J. Org. Chem. 70, 1262–1268 (2005).
van den Berg, M. et al. J. Am. Chem. Soc. 122, 11539–11540 (2000).
Reetz, M. T. & Mehler, G. Angew. Chem. Int. Edn 39, 3889–3890 (2000).
Reetz, M. T., Sell, T., Meiswinkel, A. & Mehler, G. Angew. Chem. Int. Edn 42, 790–793 (2003).
Miller, J. A., Gross, B. A., Zhuravel, M. A., Jin, W. & Nguyen, S. T. Angew. Chem. Int. Edn 44, 3885–3889 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hartwig, J. Recipes for excess. Nature 437, 487–488 (2005). https://doi.org/10.1038/437487a
Published:
Issue Date:
DOI: https://doi.org/10.1038/437487a
- Springer Nature Limited
This article is cited by
-
Enantioconvergent hydrogenations
Nature Catalysis (2018)
-
High throughput screening of Monophos instant ligand library leads to a ton-scale asymmetric hydrogenation process
Topics in Catalysis (2006)