As cancer develops, at least two cell processes are disrupted — cell growth is promoted, and cell death inhibited. It seems that mutated versions of the notorious cancer-promoting protein MYC can accomplish both at once.
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References
Hemann, M. T. et al. Nature 436, 807–811 (2005).
Chang, D. W., Claassen, G. F., Hann, S. R. & Cole, M. D. Mol. Cell. Biol. 20, 4309–4319 (2000).
Egle, A., Harris, A. W., Bouillet, P. & Cory, S. Proc. Natl Acad. Sci. USA 101, 6164–6169 (2004).
Wu, S. et al. Oncogene 22, 351–360 (2003).
Seoane, J., Le, H. V. & Massagué, J. Nature 419, 729–734 (2002).
Collins, N. L. et al. Mol. Cell. Biol. 25, 5282–5291 (2005).
Schmitt, C. A. et al. Cell 109, 335–346 (2002).
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Berns, A. Two in one. Nature 436, 787–789 (2005). https://doi.org/10.1038/436787a
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DOI: https://doi.org/10.1038/436787a
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