Breast cancers arise when the BRCA2 protein is defective, but what does the normal enzyme do? Studies of a relative of BRCA2 reveal a capacity to initiate the repair of broken DNA by loading a repair protein.
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References
Wooster, R. et al. Nature 378, 789–792 (1995).
Yang, H., Li, Q., Fan, J., Holloman, W. K. & Pavletich, N. P. Nature 433, 653–657 (2005).
Wong, A. K. C., Pero, R., Ormonde, P. A., Tavtigian, S. V. & Bartel, P. L. J. Biol. Chem. 272, 31941–31944 (1997).
Chen, C. F. et al. J. Biol. Chem. 274, 32931–32935 (1999).
Davies, A. A. et al. Mol. Cell 7, 273–282 (2001).
Pellegrini, L. et al. Nature 420, 287–293 (2002).
Shinohara, A. & Ogawa, T. Nature 391, 404–407 (1998).
New, J. H., Sugiyama, T., Zaitseva, E. & Kowalczykowski, S. C. Nature 391, 407–410 (1998).
Beernink, H. T. & Morrical, S. W. Trends Biochem. Sci. 24, 385–389 (1999).
Sung, P., Krejci, L. Van Komen, S. & Sehorn, M. G. J. Biol. Chem. 278, 42729–42732 (2003).
Yang, H. et al. Science 297, 1837–1848 (2002).
Kowalczykowski, S. C. Nature Struct. Biol. 9, 897–899 (2002).
Kojic, M. et al. Mol. Cell 10, 683–691 (2002).
Morimatsu, K. & Kowalczykowski, S. C. Mol. Cell 11, 1337–1347 (2003).
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Kowalczykowski, S. Catalyst of a catalyst. Nature 433, 591–592 (2005). https://doi.org/10.1038/433591a
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DOI: https://doi.org/10.1038/433591a
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