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DNA repair

Big engine finds small breaks

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When a break occurs in the DNA double helix, it must be dealt with rapidly. The structure of one of the cellular machines responsible is now revealed, offering insights into its impressive speed and flexibility.

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Figure 1: Heavy machinery for dealing with DNA breaks.

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Authors and Affiliations

  1. Department of Molecular Biophysics and Biochemistry, and the Howard Hughes Medical Institute, Yale University, 266 Whitney Avenue, New Haven, 06520, Connecticut, USA

    Anna Marie Pyle

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  1. Anna Marie Pyle
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Pyle, A. Big engine finds small breaks. Nature 432, 157–158 (2004). https://doi.org/10.1038/432157a

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