Using an integrated approach, it is possible to identify the molecular addresses on blood-vessel walls that are read by blood cells — and, at least in rats, to deliver imaging agents and drugs to specific tissues.
References
Miller, M. J., Wei, S. H., Cahalan, M. D. & Parker, I. Proc. Natl Acad. Sci. USA 100, 2604–2609 (2003).
M'Rini, C. et al. J. Exp. Med. 198, 1301–1312 (2003).
Condeelis, J. & Segall, J. E. Nature Rev. Cancer 3, 921–930 (2003).
Cahalan, M. D., Parker, I., Wei, S. H. & Miller, M. J. Curr. Opin. Immunol. 15, 372–377 (2003).
Folkman, J. Cancer Cell 1, 113–115 (2002).
Oh, P. et al. Nature 429, 629–635 (2004).
Pasqualini, R. & Ruoslahti, E. Nature 380, 364–366 (1996).
Pasqualini, R., Arap, W. & McDonald, D. M. Trends Mol. Med. 8, 563–571 (2002).
Hood, J. D. et al. Science 296, 2404–2407 (2002).
Oh, P. & Schnitzer, J. E. J. Biol. Chem. 274, 23144–23154 (1999).
Cowan, C. M. et al. Nature Biotechnol. 22, 560–567 (2004).
Murry, C. E. et al. Nature 428, 664–668 (2004).
Balsam, L. B. et al. Nature 428, 668–673 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Contag, C., Bachmann, M. The writing is on the vessel wall. Nature 429, 618–619 (2004). https://doi.org/10.1038/429618a
Issue Date:
DOI: https://doi.org/10.1038/429618a
- Springer Nature Limited