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Turning the key on p53

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The p53 protein is among the most effective of the body's natural defences against cancer. News comes of a promising way of releasing the protein from its inhibitions to carry out its anti-tumour duties.

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Figure 1: Inhibiting the inhibitor.

References

  1. Lane, D. P. & Crawford, L. V. Nature 278, 261–263 (1979).

    Article  ADS  CAS  Google Scholar 

  2. Vousden, K. H. & Lu, X. Nature Rev. Cancer 2, 594–604 (2002).

    Article  CAS  Google Scholar 

  3. Surendran, A. Nature Med. 10, 9 (2004).

    Article  Google Scholar 

  4. Snyder, E. L. et al. PLoS Biol. doi: 10.1371/journal.pbio.0020036 (2004).

  5. Vassilev, L. T. et al. Science 303, 844–848 (2004).

    Article  ADS  CAS  Google Scholar 

  6. Gudkov, A. V. & Komarova, E. A. Nature Rev. Cancer 3, 117–129 (2003).

    Article  CAS  Google Scholar 

  7. Iwakuma, T. & Lozano, G. Mol. Cancer Res. 1, 993–1000 (2003).

    CAS  PubMed  Google Scholar 

  8. Montes de Oca Luna, R., Wagner, D. S. & Lozano, G. Nature 378, 203–206 (1995).

    Article  ADS  CAS  Google Scholar 

  9. Chene, P. Nature Rev. Cancer 3, 102–109 (2003).

    Article  ADS  CAS  Google Scholar 

  10. Mendrysa, S. M. et al. Mol. Cell. Biol. 23, 462–473 (2003).

    Article  CAS  Google Scholar 

  11. O'Leary, K. A. et al. Mol. Cell. Biol. 24, 186–191 (2004).

    Article  CAS  Google Scholar 

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Lane, D., Fischer, P. Turning the key on p53. Nature 427, 789–790 (2004). https://doi.org/10.1038/427789a

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