The p53 protein is among the most effective of the body's natural defences against cancer. News comes of a promising way of releasing the protein from its inhibitions to carry out its anti-tumour duties.
References
Lane, D. P. & Crawford, L. V. Nature 278, 261–263 (1979).
Vousden, K. H. & Lu, X. Nature Rev. Cancer 2, 594–604 (2002).
Surendran, A. Nature Med. 10, 9 (2004).
Snyder, E. L. et al. PLoS Biol. doi: 10.1371/journal.pbio.0020036 (2004).
Vassilev, L. T. et al. Science 303, 844–848 (2004).
Gudkov, A. V. & Komarova, E. A. Nature Rev. Cancer 3, 117–129 (2003).
Iwakuma, T. & Lozano, G. Mol. Cancer Res. 1, 993–1000 (2003).
Montes de Oca Luna, R., Wagner, D. S. & Lozano, G. Nature 378, 203–206 (1995).
Chene, P. Nature Rev. Cancer 3, 102–109 (2003).
Mendrysa, S. M. et al. Mol. Cell. Biol. 23, 462–473 (2003).
O'Leary, K. A. et al. Mol. Cell. Biol. 24, 186–191 (2004).
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Lane, D., Fischer, P. Turning the key on p53. Nature 427, 789–790 (2004). https://doi.org/10.1038/427789a
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DOI: https://doi.org/10.1038/427789a
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