At the junctions between two neurons, the machinery that releases neurotransmitter from one cell must lie near calcium channels and align with detectors in the receiving cell. We now have a better idea how this occurs.
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References
Missler, M. et al. Nature 423, 939–948 (2003).
Katz, B. & Miledi, R. Proc. R. Soc. Lond. B Biol. Sci. 161, 496–503 (1965).
Smith, S. J. & Augustine, G. J. Trends Neurosci. 11, 458–464 (1988).
Atlas, D. J. Neurochem. 77, 972–985 (2001).
Ushkaryov, Y. A., Petrenko, A. G., Geppert, M. & Südhof, T. C. Science 257, 50–56 (1992).
Ulrich, B., Ushkaryov, Y. A. & Südhof, T. C. Neuron 14, 497–507 (1995).
Ichtchenko, K. Y. et al. Cell 81, 435–443 (1995).
Sugita, S. et al. J. Cell Biol. 154, 435–445 (2001).
Scheiffele, P., Fan, J., Choih, J., Fetter, R. & Serafini, T. Cell 101, 657–669 (2000).
Garner, C. C., Nash, J. & Huganir, R. L. Trends Cell Biol. 10, 274–280 (2000).
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Littleton, J., Sheng, M. Synapses unplugged. Nature 423, 931–932 (2003). https://doi.org/10.1038/423931a
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DOI: https://doi.org/10.1038/423931a
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