Skip to main content
SpringerLink
Log in

Molecular biology

A fix for RNA

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

It has long been known that cells repair chemically or physically damaged DNA. But the discovery that damaged RNA can also be repaired may come as a surprise. What's more, some of the same enzymes are involved.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Major biological molecules and the consequences of damage to them.
Figure 2: Mechanism for repairing damaged RNA and DNA.

References

  1. Aas, P. A. et al. Nature 421, 859–863 (2003).

    Article  ADS  CAS  Google Scholar 

  2. Falnes, P. O., Johansen, R. F. & Seeberg, E. Nature 419, 178–182 (2002).

    Article  ADS  CAS  Google Scholar 

  3. Trewick, S. C., Henshaw, T. F., Hausinger, R. P., Lindahl, T. & Sedgwick, B. Nature 419, 174–178 (2002).

    Article  ADS  CAS  Google Scholar 

  4. Duncan, T. et al. Proc. Natl Acad. Sci. USA 99, 16660–16665 (2002).

    Article  ADS  CAS  Google Scholar 

  5. Friedberg, E. C., Walker, G. C. & Siede, W. DNA Repair and Mutagenesis (Am. Soc. Microbiol., Washington DC, 1995).

    Google Scholar 

  6. Aravind, L. & Koonin, E. V. Genome Biol. 2 (3), 1–8 (2001).

    Article  Google Scholar 

  7. Karran, P. Proc. Natl Acad. Sci. USA 82, 5285–5289 (1985).

    Article  ADS  CAS  Google Scholar 

  8. Wei, Y. F., Carter, K. C., Wang, R. P. & Shell, B. K. Nucleic Acids Res. 24, 931–937 (1996).

    Article  CAS  Google Scholar 

  9. Nissen, P., Hansen, J., Ban, N., Moore, P. B. & Steitz, T. A. Science 289, 920–930 (2000).

    Article  ADS  CAS  Google Scholar 

  10. Gottesman, S. Genes Dev. 16, 2829–2842 (2002).

    Article  CAS  Google Scholar 

  11. Reichert, A. S. & Morl, M. Nucleic Acids Res. 28, 2043–2048 (2000).

    Article  CAS  Google Scholar 

  12. http://medlib.med.utah.edu/RNAmods

Download references

Author information

Authors and Affiliations

  1. Biological Engineering Division, and the Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, 02139, Massachusetts, USA

    Thomas J. Begley & Leona D. Samson

Authors
  1. Thomas J. Begley
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Leona D. Samson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Leona D. Samson.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Begley, T., Samson, L. A fix for RNA. Nature 421, 795–796 (2003). https://doi.org/10.1038/421795a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/421795a

  • Springer Nature Limited

This article is cited by

Search

Navigation