Growth factors regulate cell behaviour, and are kept in check by inhibitors. The structure of a complex of two such proteins shows that they form back-to-back butterflies, with the inhibitor's wings stretching to embrace its partner.
This is a preview of subscription content, log in via an institution to check access.
References
Groppe, J. et al. Nature 420, 636–642 (2002).
Urist, M. R. Science 150, 893–899 (1965).
Hogan, B. L. M. Genes Dev. 10, 1580–1594 (1996).
Kirsch, T., Sebald, W. & Dreyer, M. K. Nature Struct. Biol. 7, 492–496 (2000).
Hart, P. J. et al. Nature Struct. Biol. 9, 203–208 (2002).
Smith, W. C. & Harland, R. M. Cell 70, 829–840 (1992).
Gong, Y. et al. Nature Genet. 21, 302–304 (1999).
Vitt, U. A., Hsu, S. Y. & Hsueh, A. J. Mol. Endocrinol. 15, 681–694 (2001).
Capdevila, J. & Izpisua Belmonte, J. C. Annu. Rev. Cell Dev. Biol. 17, 87–132 (2001).
Piccolo, S. et al. Nature 397, 707–709 (1999).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wrana, J. On the wings of inhibition. Nature 420, 613–614 (2002). https://doi.org/10.1038/420613a
Issue Date:
DOI: https://doi.org/10.1038/420613a
- Springer Nature Limited