Cyclooxygenase enzymes produce lipid messenger molecules whose roles in health or disease depend on their context. The discovery of cyclooxygenase-3 should enhance our knowledge of such events.
References
Chandrasekharan, N. et al. Proc. Natl Acad. Sci. USA 99, 13926–13931 (2002).
Vane, J. R. Nature New Biol. 231, 232–235 (1971).
Flower, R. J. & Vane, J. R. Nature 240, 410–411 (1972).
Xie, W. L., Chipman, J. G., Robertson, D. L., Erikson, R. L. & Simmons, D. L. Proc. Natl Acad. Sci. USA 88, 2692–2696 (1991).
Fletcher, B. S., Kujubu, D. A., Perrin, D. M. & Herschman, H. R. J. Biol. Chem. 267, 4338–4344 (1992).
Marcheselli, V. L. & Bazan, N. G. J. Biol. Chem. 271, 24794–24799 (1996).
Bazan, N. G. Nature Med. 7, 414–415 (2001).
Warner, T. D. et al. Proc. Natl Acad. Sci. USA 96, 7563–7568 (1999).
Simmons, D. L., Botting, R. M., Robertson, P. M., Madsen, M. L. & Vane, J. R. Proc. Natl Acad. Sci. USA 96, 3275–3280 (1999).
Chen, C., Magee, J. & Bazan, N. J. Neurophysiol. 87, 2851–2857 (2002).
Kolko, M., DeCoster, M. A., Rodriguez de Turco, E. B. & Bazan, N. G. J. Biol. Chem. 271, 32722–32728 (1996).
Dinh, T. P. et al. Proc. Natl Acad. Sci. USA 99, 10819–10824 (2002).
Walker, J. M., Huang, S. M., Strangman, N. M., Tsou, K. & Sañudo-Peña, M. C. Proc. Natl Acad. Sci. USA 96, 12198–12203 (1999).
Prusakiewicz, J. J., Kingsley, P. J., Kozak, K. R. & Marnett, L. J. Biochem. Biophys. Res. Commun. 296, 612–617 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bazan, N., Flower, R. Lipid signals in pain control. Nature 420, 135–138 (2002). https://doi.org/10.1038/420135a
Issue Date:
DOI: https://doi.org/10.1038/420135a
- Springer Nature Limited
This article is cited by
-
Cyclooxygenase-2 Immunoreactivity and Protein Level in the Gerbil Hippocampus During Normal Aging
Neurochemical Research (2010)
-
Antipyretic treatment of noninfectious fever in children with severe traumatic brain injury
Child's Nervous System (2008)
-
Mechanism of chronic urticaria exacerbation by aspirin
Current Allergy and Asthma Reports (2005)
-
Alzheimer’s Disease—A Dysfunction in Cholesterol and Lipid Metabolism
Cellular and Molecular Neurobiology (2005)
-
The development of COX2 inhibitors
Nature Reviews Drug Discovery (2003)