The discovery that a transcriptional repressor is turned on in prostate tumours as they become metastatic, leading to the silencing of many genes, suggests a new mechanism for tumour progression.
References
Nowell, P. C. Science 194, 23–28 (1976).
Hanahan, D. & Weinberg, R. A. Cell 100, 57–70 (2000).
Varambally, S. et al. Nature 419, 624–629 (2002).
Dhanasekaran, S. M. et al. Nature 412, 822–826 (2001).
Laible, G. et al. EMBO J. 16, 3219–3232 (1997).
LaTulippe, E. et al. Cancer Res. 62, 4499–4506 (2002).
van Kemenade, F. J. et al. Blood 97, 3896–3901 (2001).
Chakravatri, A. et al. Urology 55, 635–638 (2000).
McMenamin, M. E. et al. Cancer Res. 59, 4291–4296 (1999).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Zetter, B., Banyard, J. The silence of the genes. Nature 419, 572–573 (2002). https://doi.org/10.1038/419572a
Issue Date:
DOI: https://doi.org/10.1038/419572a
- Springer Nature Limited
This article is cited by
-
Molecular biology of prostate cancer
Prostate Cancer and Prostatic Diseases (2004)