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The silence of the genes

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The discovery that a transcriptional repressor is turned on in prostate tumours as they become metastatic, leading to the silencing of many genes, suggests a new mechanism for tumour progression.

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Figure 1: Tumour progression and transcriptional repressor proteins.

References

  1. Nowell, P. C. Science 194, 23–28 (1976).

    Article  ADS  CAS  Google Scholar 

  2. Hanahan, D. & Weinberg, R. A. Cell 100, 57–70 (2000).

    Article  CAS  Google Scholar 

  3. Varambally, S. et al. Nature 419, 624–629 (2002).

    Article  ADS  CAS  Google Scholar 

  4. Dhanasekaran, S. M. et al. Nature 412, 822–826 (2001).

    Article  ADS  CAS  Google Scholar 

  5. Laible, G. et al. EMBO J. 16, 3219–3232 (1997).

    Article  CAS  Google Scholar 

  6. LaTulippe, E. et al. Cancer Res. 62, 4499–4506 (2002).

    CAS  PubMed  Google Scholar 

  7. van Kemenade, F. J. et al. Blood 97, 3896–3901 (2001).

    Article  CAS  Google Scholar 

  8. Chakravatri, A. et al. Urology 55, 635–638 (2000).

    Article  CAS  Google Scholar 

  9. McMenamin, M. E. et al. Cancer Res. 59, 4291–4296 (1999).

    CAS  PubMed  Google Scholar 

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Correspondence to Bruce R. Zetter or Jacqueline Banyard.

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Zetter, B., Banyard, J. The silence of the genes. Nature 419, 572–573 (2002). https://doi.org/10.1038/419572a

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