Skip to main content
SpringerLink
Log in

DNA repair

Right on target with ubiquitin

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

Cellular DNA-repair mechanisms prevent mutations from accumulating, thereby averting defects in cell function. A molecule best known for its role in protein degradation is now shown to have a specific task in DNA repair.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Connecting DNA repair and ubiquitin, through the PCNA protein.

References

  1. Hershko, A. & Ciechanover, A. Annu. Rev. Biochem. 67, 425–479 (1998).

    Article  CAS  Google Scholar 

  2. Pickart, C. M. Trends Biochem. Sci. 25, 544–548 (2000).

    Article  CAS  Google Scholar 

  3. Reynolds, P., Weber, S. & Prakash, L. Proc. Natl Acad. Sci. USA 82, 168–172 (1985).

    Article  ADS  CAS  Google Scholar 

  4. Jentsch, S., McGrath, J. P. & Varshavsky, A. Nature 329, 131–134 (1987).

    Article  ADS  CAS  Google Scholar 

  5. Hoege, C., Pfander, B., Moldovan, G.-L, Pyrowolakis, G. & Jentsch, S. Nature 419, 135–141 (2002).

    Article  ADS  CAS  Google Scholar 

  6. Hoeijmakers, J. H. J. Nature 411, 366–374 (2001).

    Article  ADS  CAS  Google Scholar 

  7. Broomfield, S., Hryciw, T. & Xiao, W. Mutat. Res. 486, 167–184 (2001).

    Article  CAS  Google Scholar 

  8. Spence, J., Sadis, S., Haas, A. L. & Finley, D. Mol. Cell. Biol. 15, 1265–1273 (1995).

    Article  CAS  Google Scholar 

  9. Warbrick, E. BioEssays 22, 997–1006 (2000).

    Article  CAS  Google Scholar 

  10. Hochstrasser, M. Nature Cell Biol. 2, E153–E157 (2000).

    Article  CAS  Google Scholar 

  11. Desterro, J. M., Rodriguez, M. S. & Hay, R. T. Mol. Cell 2, 233–239 (1998).

    Article  CAS  Google Scholar 

  12. Ulrich, H. D. & Jentsch, S. EMBO J. 19, 3388–3397 (2000).

    Article  CAS  Google Scholar 

  13. Torres-Ramos, C., Yoder, B. L., Bugers, P. M. J., Prakash, S. & Prakash, L. Proc. Natl Acad. Sci. USA 93, 9676–9681 (1996).

    Article  ADS  CAS  Google Scholar 

  14. Torres-Ramos, C. A., Prakash, S. & Prakash, L. J. Biol. Chem. 272, 25445–25448 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, 21205, Maryland, USA

    Cecile M. Pickart

Authors
  1. Cecile M. Pickart
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Cecile M. Pickart.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pickart, C. Right on target with ubiquitin. Nature 419, 120–121 (2002). https://doi.org/10.1038/419120a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/419120a

  • Springer Nature Limited

This article is cited by

Search

Navigation