Just as important as starting cellular signalling pathways is switching them off again. It seems that the Cbl protein has a dual function in accelerating the degradation of certain signalling molecules.
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References
Soubeyran, P., Kowanetz, K., Szymkiewicz, I., Langdon, W. Y. & Dikic, I. Nature 416, 183–187 (2002).
Petrelli, A. et al. Nature 416, 187–190 (2002).
Yoon, C. H., Lee, J., Jongeward, G. D. & Sternberg, P. W. Science 269, 1102–1105 (1995).
Thien, C. B. & Langdon, W. Y. Nature Rev. Mol. Cell Biol. 2, 294–307 (2001).
Hicke, L. & Riezman, H. Cell 84, 277–287 (1996).
Ringstad, N. et al. Neuron 24, 143–154 (1999).
Schmidt, A. et al. Nature 401, 133–141 (1999).
Farsad, K. et al. J. Cell Biol. 155, 193–200 (2001).
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Oved, S., Yarden, Y. Molecular ticket to enter cells. Nature 416, 133–136 (2002). https://doi.org/10.1038/416133a
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DOI: https://doi.org/10.1038/416133a
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