Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive age-dependent disease involving degeneration of motor neurons in the brain, brainstem and spinal cord. ALS is universally fatal, with the median survival of patients being five years from diagnosis. In a transgenic mouse model of ALS, we now show that a dominant negative inhibitor of a cell-death gene, the interleukin-1β-converting enzyme (ICE), significantly slows the symptomatic progression of ALS.
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Friedlander, R., Brown, R., Gagliardini, V. et al. Inhibition of ICE slows ALS in mice. Nature 388, 31 (1997). https://doi.org/10.1038/40299
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DOI: https://doi.org/10.1038/40299
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