This year's Nobel prize in physiology or medicine was awarded for the discovery, in 1974, of a fundamental principle in immunology. The underlying interactions are now being seen in three dimensions.
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Parham, P. Pictures of MHC restriction. Nature 384, 109–110 (1996). https://doi.org/10.1038/384109a0
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DOI: https://doi.org/10.1038/384109a0
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