Abstract
A PHEROMONE-INDUCED neurosecretory pathway in Caenorhabditis elegans triggers developmental arrest and an increase in longevity at the dauer diapause stage. The gene age-1 is required for non-dauer development and normal senescence, age-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase (PI(3)K) catalytic subunits. Lack of both maternal and zygotic age-1 activity causes dauer formation, whereas animals with maternal but not zygotic age-1 activity develop as non-dauers that live more than twice as long as normal. These data suggest that phosphatidylinositol signalling mediated by AGE-1 protein controls lifespan and the dauer diapause decision.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Riddle, D. L. in The Dauer Larva in the Nematode Caenorhabditis elegans (ed. Wood, W. B.) 393–412 (Cold Spring Harbor Laboratory Press, NY, 1988).
Sato, Y., Ikeda, M. & Yamashita, O. gen. Comp. Endocr. 96, 27–36 (1994).
Riddle, D. L., Swanson, M. M. & Albert, P. S. Nature 290, 668–671 (1981).
Vowels, J. J. & Thomas, J. H. Genetics 130, 105–123 (1992).
Gottlieb, S. & Ruvkun, G. Genetics 137, 107–120 (1994).
Thomas, J. H., Birnby, D. A. & Vowels, J. J. Genetics 134, 1105–1117 (1993).
Kenyon, C., Chang, J., Gensch, E., Rudner, A. & Tabtiang, R. Nature 366, 461–464 (1993).
Larsen, P. L., Albert, P. S. & Riddle, D. L. Genetics 139, 1567–1583 (1995).
Klass, M. Mech. Aging Dev. 22, 279–286 (1983).
Friedman, D. B. & Johnson, T. E. Genetics 118, 75–86 (1988).
Sulston, J. et al. Nature 356, 37–41 (1992).
Kapeller, R. & Cantley, L. C. Bioessays 16, 565–576 (1994).
Hunter, T. Cell 83, 1–4 (1995).
Franke, T. F. et al. Cell 81, 727–736 (1995).
Burgering, B. M. T. & Coffer, P. J. Nature 376, 599–602 (1995).
Pons, S. et al. Molec. Cell. Biol. 15, 4453–4465 (1995).
Carpenter, C. L. et al. Molec. cell. Biol. 13, 1657–1665 (1993).
Dhand, R. et al. EMBO J. 13, 511–521 (1994).
Stoyanov, B. et al. Science 269, 690–693 (1995).
Kimura, K. et al. J. Biol. Chem. 269, 18961–18967 (1994).
Yao, R. & Cooper, G. M. Science 267, 2003–2006 (1995).
Yano, H. et al. J. Biol. Chem. 268, 25846–25856 (1993).
Levy-Toledano, R., Taouis, M., Blaettler, D. H., Gorden, P. & Taylor, S. I. J. Biol. Chem. 269, 31178–31182 (1994).
Finch, C. E. Longevity, Senescence, and the Genome (Univ. Chicago Press, 1990).
Larsen, P. Proc. Natl. Acad. Sci. U.S.A. 90, 8905–8909 (1993).
VanFleteren, J. R. Biochem. J. 292, 605–608 (1993).
Okada, T., Kawano, Y., Sakakibara, T., Hazeki, O. & Ui, M. J. Biol. Chem. 269, 3563–3567 (1994).
Thelen, M., Wymann, M. P. & Langen, H. Proc. Natl. Acad. Sci. U.S.A. 91, 4960–4964 (1994).
Dorman, J. B. et al. Genetics 141, 1399 (1995).
Rodriguez-Viciana, P. et al. EMBO J. 15, 2442–2451 (1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Morris, J., Tissenbaum, H. & Ruvkun, G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382, 536–539 (1996). https://doi.org/10.1038/382536a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/382536a0
- Springer Nature Limited
This article is cited by
-
Evaluation of Paecilomyces tenuis producing Huperzine A for the management of root-knot nematode Meloidogyne incognita (Nematoda: Meloidogynidae)
Journal of Pest Science (2023)
-
Banking on a new understanding: translational opportunities from veterinary biobanks
GeroScience (2023)
-
Caenorhabditis elegans DAF-16 regulates lifespan and immune responses to Cryptococcus neoformans and Cryptococcus gattii infections
BMC Microbiology (2022)
-
Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost
Nature Communications (2022)
-
The hypothalamus for whole-body physiology: from metabolism to aging
Protein & Cell (2022)