Abstract
ACTIVE membrane mechanisms have been found in the dendrites of many nerve cells1–7. Their contribution to dendritic signal processing, however, remains unclear8 because few experimental preparations allow for detailed characterization of dendritic physiology under normal conditions. To investigate the functional implications of active dendritic processes in an in vivo preparation, we compared the response properties of different types of non-spiking, motion-sensitive interneurons of the fly visual system, only one of which is equipped with a fast sodium inward current in its axon as well as in its dendrite. We report here that cells with fast activating sodium currents can respond to temporal changes in their synaptic input signals up to much higher frequencies than can those which lack such currents. Thus fast sodium currents lead to a frequency-dependent amplification of synaptic signals, enhancing cellular responses specifically to transient inputs which otherwise would be attenuated because of the passive properties of the dendritic tree.
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References
Spencer, W. A. & Kandel, E. R. J. Neurophysiol. 24, 272–285 (1961).
Stuart, G. J. & Sakmann, B. Nature 367, 69–72 (1994).
Spruston, N., Schiller, Y., Stuart, G. & Sakmann, B. Science 268, 297–300 (1995).
Magee, J. C. & Johnston, D. Science 268, 301–304 (1995).
Llinas, R. R. Science 242, 1654–1664 (1988).
Laurent, G. J. Physiol., Lond. 470, 45–54 (1993).
Yuste, R., Gutnick, M. J., Saar, D., Delaney, K. R. & Tank, D. W. Neuron 13, 23–43 (1994).
Bemander, O., Koch, C. & Douglas, R. J. J. Neurophysiol. 72, 2743–2753 (1994).
Hausen, K. in Photoreception and Vision in Invertebrates (ed. Ali, M. A.) 523–559 (Plenum, New York, 1984).
Egelhaaf, M. & Borst, A. J. Neurosci. 13, 4563–4574 (1993).
Strausfeld, N. J. in Photoreception and Vision in Invertebrates (ed. Ali, M. A.) 483–522 (Plenum, New York, 1984).
Borst, A. & Egelhaaf, M. Proc. natn. Acad. Sci. U.S.A. 89, 4139–4143 (1992).
Haag, J., Egelhaaf, M. & Borst, A. Neurosci. Lett. 140, 173–176 (1992).
Hengstenberg, R. Nature 270, 338–340 (1977).
Hausen, K. Z. Naturforsch. 31c, 629–633 (1976).
Eckert, H. & Dvorak, D. R. J. Insect Physiol. 29, 547–560 (1983).
Egelhaaf, M., Borst, A., Warzecha, A. K., Flecks, S. & Wildemann, A. J. Neurophysiol. 69, 340–351 (1993).
Hausen, K. Biol. Cybern. 45, 143–156 (1982).
Hausen, K. Biol. Cybern. 46, 67–79 (1982).
Haag, J. thesis, Univ. Tuebingen (1994).
Borst, A., Egelhaaf, M. & Haag, J. J. comput. Neurosci. 2, 5–18 (1995).
Reichardt, W. J. comp. Physiol. A161, 533–547 (1987).
Borst, A. & Egelhaaf, M. Trends Neurosci. 12, 297–306 (1989).
Borst, A. & Egelhaaf, M. in Visual Motion and its Role in the Stabilization of Gaze (eds Miles, F. A. & Wallman, J.) 3–27 (Elsevier, Amsterdam, 1993).
Gauck, V., Egelhaaf, M. & Borst, A. in Göttingen Neurobiology Report 1994 (eds Elsner, N. & Breer, H.) 445 (Thieme, Stuttgart, 1994).
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Haag, J., Borst, A. Amplification of high-frequency synaptic inputs by active dendritic membrane processes. Nature 379, 639–641 (1996). https://doi.org/10.1038/379639a0
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DOI: https://doi.org/10.1038/379639a0
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