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Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

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Abstract

Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressers of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.

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References

  1. Chambon, P. Sem. Cell Biol. 5, 115–125 (1994).

    Article  CAS  Google Scholar 

  2. Yu, V. C. et al. Cell 67, 1251–1266 (1991).

    Article  CAS  Google Scholar 

  3. Leid, M. et al. Cell 68, 377–395 (1992).

    Article  CAS  Google Scholar 

  4. Kliewer, S. A., Umesono, K., Mangelsdorf, D. J. & Evans, R. M. Nature 355, 446–449 (1992).

    Article  ADS  CAS  Google Scholar 

  5. Marks, M. S. et al. EMBO J. 11, 1419–1435 (1992).

    Article  CAS  Google Scholar 

  6. Zhang, X. K., Hoffmann, B., Tran, P. B. V., Graupner, G. & Pfahl, M. Nature 355, 441–446 (1992).

    Article  ADS  CAS  Google Scholar 

  7. Graf, T. & Beug, H. Cell 34, 7–9 (1983).

    Article  CAS  Google Scholar 

  8. Sap, J. et al. Nature 324, 635–640 (1986).

    Article  ADS  CAS  Google Scholar 

  9. Weinberger, C. et al. Nature 324, 641–646 (1986).

    Article  ADS  CAS  Google Scholar 

  10. Munoz, A. et al. EMBO J. 7, 155–159 (1988).

    Article  CAS  Google Scholar 

  11. Sap, J., Munoz, A., Schmitt, J., Stunnenberg, H. & Vennström, B. Nature 340, 242–244 (1989).

    Article  ADS  CAS  Google Scholar 

  12. Brent, G. A. et al. New Biol. 1, 329–336 (1989).

    CAS  PubMed  Google Scholar 

  13. Damm, K., Thompson, C. C. & Evans, R. Nature 339, 593–597 (1989).

    Article  ADS  CAS  Google Scholar 

  14. Graupner, G., Wills, K. N., Tzukerman, M., Zhang, X.-K. & Pfahl, M. Nature 340, 653–656 (1989).

    Article  ADS  CAS  Google Scholar 

  15. Disela, C. et al. Genes Dev. 5, 2033–2047 (1991).

    Article  CAS  Google Scholar 

  16. Sharif, M. & Privalsky, M. L. Cell 66, 885–893 (1991).

    Article  CAS  Google Scholar 

  17. Baniahmad, A., Steiner, C., Köhne, A. C. & Renkawitz, R. Cell 61, 505–514 (1990).

    Article  CAS  Google Scholar 

  18. Baniahmad, A., Tsai, S. Y., O'Malley, B. W. & Tsai, M. J. Proc. natn. Acad. Sci. U.S.A. 89, 10633–10637 (1992).

    Article  ADS  CAS  Google Scholar 

  19. Renkawitz, R. Ann. N.Y. Acad. Sci. 684, 1–10 (1993).

    Article  ADS  CAS  Google Scholar 

  20. Holloway, J. M., Glass, C. K., Adler, S., Nelson, C. A. & Rosenfeld, M. G. Proc. natn. Acad. Sci. U.S.A. 87, 8160–8164 (1989).

    Article  ADS  Google Scholar 

  21. Baniahmad, A., Köhne, A. C. & Renkawitz, R. EMBO J. 11, 1015–1023 (1992).

    Article  CAS  Google Scholar 

  22. Martin, B., Renkawitz, R. & Müller, M. Nucleic Acids Res. 22, 4899–4905 (1994).

    Google Scholar 

  23. Ing, N. H., Beekman, J. M., Tsai, S. Y., Tsai, M. J. & O'Malley, B. W. J. biol. Chem. 262, 17617–17623 (1992).

    Google Scholar 

  24. Baniahmad, A. et al. Proc. natn. Acad. Sci. U.S.A. 90, 8832–8836 (1993).

    Article  ADS  CAS  Google Scholar 

  25. Fondell, J. D., Roy, A. L. & Roeder, R. G. Genes Dev. 7, 1400–1410 (1993).

    Article  CAS  Google Scholar 

  26. Blanco, J. C. et al. Proc. natn. Acad. Sci. U.S.A. 92, 1535–1539 (1995).

    Article  ADS  CAS  Google Scholar 

  27. Damm, K. & Evans, R. M. Proc. natn. Acad. Sci. U.S.A. 90, 10668–10672 (1993).

    Article  ADS  CAS  Google Scholar 

  28. Baniahmad, A. et al. Molec. cell. Biol. 15, 76–86 (1995).

    Article  CAS  Google Scholar 

  29. Casanova, J. et al. Molec. cell. Biol. 14, 5756–5765 (1994).

    Article  CAS  Google Scholar 

  30. Cavailles, v., Dauvois, S., Danielian, P. S. & Parker, M. G. Proc. natn. Acad. Sci. U.S.A. 91, 10009–10013 (1994).

    Article  ADS  CAS  Google Scholar 

  31. Halachmi, S. et al. Science 264, 1455–1458 (1994).

    Article  ADS  CAS  Google Scholar 

  32. Kurokawa, R. et al. Nature 377, 451–454 (1995).

    Article  ADS  CAS  Google Scholar 

  33. Fields, S. & Song, O. Nature 340, 245–246 (1989).

    Article  ADS  CAS  Google Scholar 

  34. Gyuris, J., Golemis, E., Chertkov, H. & Brent, R. Cell 75, 791–803 (1993).

    Article  CAS  Google Scholar 

  35. Seol, W., Choi, H. S. & Moore, D. D. Molec. Endocr. 9, 72–85 (1995).

    CAS  PubMed  Google Scholar 

  36. Licht, J. D. et al. Molec. cell. Biol. 14, 4057–4066 (1994).

    Article  CAS  Google Scholar 

  37. Madden, S. L., Cook, D. M. & Rauscher, F. J. Oncogene 8, 1713–1720 (1993).

    CAS  PubMed  Google Scholar 

  38. Saha, S., Brickman, J. M., Lehming, N. & Ptashne, M. Nature 363, 648–652 (1993).

    Article  ADS  CAS  Google Scholar 

  39. Qi, J. S., Desai-Yajnik, V., Greene, M. E., Raaka, B. M. & Samuels, H. H. Molec. cell. Biol. 15, 1817–1825 (1995).

    Article  CAS  Google Scholar 

  40. Paroush, Z. et al. Cell 79, 805–815 (1994).

    Article  CAS  Google Scholar 

  41. Komachi, K., Redd, M. J. & Johnson, A. D. Genes Dev. 8, 2857–2867 (1994).

    Article  CAS  Google Scholar 

  42. Tzamarias, D. & Struhl, K. Genes Dev. 9, 821–831 (1995).

    Article  CAS  Google Scholar 

  43. Hiebert, S. W., Chellappan, S. P., Horowitz, J. M. & Nevins, J. R. Genes Dev. 6, 177–185 (1992).

    Article  CAS  Google Scholar 

  44. Mangelsdorf, D. J. et al. Cell 66, 555–561 (1991).

    Article  CAS  Google Scholar 

  45. Willy, P. J. et al. Genes Dev. 9, 1033–1045 (1995).

    Article  CAS  Google Scholar 

  46. Koenig, R. J. et al. Nature 337, 659–661 (1989).

    Article  ADS  CAS  Google Scholar 

  47. Lazar, M. A., Hodin, R. A. & Chin, W. W. Proc. natn. Acad. Sci. USA. 86, 7771–7774 (1989).

    Article  ADS  CAS  Google Scholar 

  48. Ayer, D. E., Lawrence, Q. A. & Eisenman, R. N. Cell 80, 767–776 (1995).

    Article  CAS  Google Scholar 

  49. Schreiber-Agus, N. et al. Cell 80, 777–786 (1995).

    Article  CAS  Google Scholar 

  50. Chen, J. D. & Evans, R. M. Nature 377, 454–457 (1995).

    Article  ADS  CAS  Google Scholar 

  51. Ingraham, H. A. et al. Cell 55, 519–529 (1988).

    Article  CAS  Google Scholar 

  52. Kurokawa, R. et al. Nature 371, 528–531 (1994).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California, 92093-0648, USA

    Andreas J. Hörlein, Anders M. Näär, Thorsten Heinzel, Joseph Torchia, Bernd Gloss, Aimee Ryan, Yasutomi Kamei & Michael G. Rosenfeld

  2. Cellular and Molecular Medicine, Department and School of Medicine, University of California, San Diego, La Jolla, California, 92093-0648, USA

    Riki Kurokawa, Mats Söderström & Christopher K. Glass

  3. Graduate Program in Molecular Pathology, Department and School of Medicine, University of California, San Diego, La Jolla, California, 92093-0648, USA

    Anders M. Näär

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  1. Andreas J. Hörlein
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Hörlein, A., Näär, A., Heinzel, T. et al. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377, 397–404 (1995). https://doi.org/10.1038/377397a0

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  • DOI: https://doi.org/10.1038/377397a0

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