Abstract
THE lin-12 and glp-1 genes of Caenorhabditis elegans are members of the lin-12 / Notch family of receptors for intercellular signals that specify cell fate1,2. By screening for suppressors of a lin-12 gain-of-function mutation, we identified a new gene, sel-12, which appears to function in receiving cells to facilitate signalling mediated by lin-12 and glp-1. The sel-12 gene encodes a protein with multiple transmembrane domains, and is similar to S182, which has been implicated in early-onset familial Alzheimer's disease3. The high degree of sequence conservation suggests that the function of the SEL-12 and S182 proteins may also be conserved.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Greenwald, I. Curr. Opin. Genet. Dev. 4, 556–562 (1994).
Artavanis-Tsakonas, S., Matsuno, K. & Fortini, M. Science 268, 225–268 (1995).
Sherrington, R. et al. Nature 375, 754–760 (1995).
Greenwald, I., Sternberg, P. & Horvitz, H. R. Cell 34, 435–444 (1983).
Ferguson, E. L. & Horvitz, H. R. Nature 110, 259–267 (1985).
Brenner, S. Genetics 77, 71–94 (1974).
Kimble, J. & Hirsh, D. Devl Biol. 81, 208–221 (1979).
Kimble, J. Devl Biol. 87, 286–300 (1981).
Seydoux, G. & Greenwald, I. Cell. 57, 1237–1245 (1989).
Greenwald, I. & Seydoux, G. Nature 346, 197–199 (1990).
Sundaram, M. & Greenwald, I. Genetics 135, 755–763 (1993).
Sulston, J. & White, J. Devl Biol. 78, 577–597 (1980).
Sternberg, P. & Horvitz, H. R. Cell 44, 761–772 (1986).
Sulston, J. & Horvitz, H. R. Devl Biol. 56, 110–156 (1977).
Horvitz, H. R. & Sternberg, P. W. Nature 351, 535–541 (1991).
Simske, J. S. & Kim, S. K. Nature 375, 142–146 (1995).
Tuck, S. & Greenwald, I. Genes Dev. 9, 341–357 (1995).
Sternberg, P. W. Nature 335, 551–554 (1988).
Sternberg, P. W. & Horvitz, H. R. Cell 58, 679–693 (1989).
Beitel, G. J., Clark, S. G. & Horvitz, H. R. Nature 348, 503–509 (1990).
Han, M. & Sternberg, P. W. Cell 63, 921–931 (1990).
L'Hernault, S. W. & Arduengo, P. M. J. Cell Biol. 119, 55–68 (1992).
Lambie, E. & Kimble, J. Development 112, 231–240 (1991).
Priess, J. R., Schnabel, H. & Schnabel, R. Cell 51, 601–611 (1987).
Austin, J. & Kimble, J. Cell 51, 589–599 (1987).
Khan, A. S. et al. Nature Genet. 2, 180–185 (1992).
Coulson, A., Waterston, J., Kiff, J., Sulston, J. & Kohara, Y. Nature 235, 184–186 (1988).
Mello, C. C., Kramer, J. M., Stinchcomb, D. T. & Ambros, V. A. EMB0 J. 10, 3959–3970 (1991).
Krause, M. & Hirsh, D. Cell 49, 753–761 (1987).
Ohara, O., Dorit, R. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 86, 5673–5677 (1989).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Levitan, D., Greenwald, I. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377, 351–354 (1995). https://doi.org/10.1038/377351a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/377351a0
- Springer Nature Limited
This article is cited by
-
A somatic proteoglycan controls Notch-directed germ cell fate
Nature Communications (2021)
-
Postnatal dysregulation of Notch signal disrupts dendrite development of adult-born neurons in the hippocampus and contributes to memory impairment
Scientific Reports (2016)
-
Development of new fusion proteins for visualizing amyloid-β oligomers in vivo
Scientific Reports (2016)
-
Biological function of Presenilin and its role in AD pathogenesis
Translational Neurodegeneration (2013)