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Viral dynamics in human immunodeficiency virus type 1 infection

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Abstract

The dynamics of HIV-1 replication in vivo are largely unknown yet they are critical to our understanding of disease pathogenesis. Experimental drugs that are potent inhibitors of viral replication can be used to show that the composite lifespan of plasma virus and virus-producing cells is remarkably short (half-life ˜2 days). Almost complete replacement of wild-type virus in plasma by drug-resistant variants occurs after fourteen days, indicating that HIV-1 viraemia is sustained primarily by a dynamic process involving continuous rounds of de novo virus infection and replication and rapid cell turnover.

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Authors and Affiliations

  1. Division of Hematology/Oncology, University of Alabama at Birmingham, 613 Lyons-Harrison Research Building, 701 South 19th Street, Birmingham, Alabama, 35294, USA

    Xiping Wei, Sajal K. Ghosh, Maria E. Taylor, Beatrice H. Hahn & George M. Shaw

  2. Division of Infectious Diseases, University of Alabama at Birmingham, 613 Lyons-Harrison Research Building, 701 South 19th Street, Birmingham, Alabama, 35294, USA

    Victoria A. Johnson & Michael S. Saag

  3. Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania, 19486, USA

    Emilio A. Emini

  4. Department of Clinical Pharmacology, Merck Research Laboratories, West Point, Pennsylvania, 19486, USA

    Paul Deutsch

  5. Division of HIV and Exploratory Research, Genelabs Technologies Inc., Redwood City, California, 94063, USA

    Jeffrey D. Lifson

  6. Department of Zoology, University of Oxford, Oxford, 0X1 3PS, UK

    Sebastian Bonhoeffer & Martin A. Nowak

Authors
  1. Xiping Wei
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  2. Sajal K. Ghosh
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  3. Maria E. Taylor
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  4. Victoria A. Johnson
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  5. Emilio A. Emini
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  6. Paul Deutsch
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  7. Jeffrey D. Lifson
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  8. Sebastian Bonhoeffer
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  9. Martin A. Nowak
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  10. Beatrice H. Hahn
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  11. Michael S. Saag
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  12. George M. Shaw
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Wei, X., Ghosh, S., Taylor, M. et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373, 117–122 (1995). https://doi.org/10.1038/373117a0

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  • DOI: https://doi.org/10.1038/373117a0

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