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Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma

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Abstract

Basic fibroblast growth factor (bFGF) and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice. Synergy is due to Tat, which enhances endothelial cell growth and type-IV collagenase expression in response to bFGF mimicking extracellular matrix proteins. The bFGF, extracellular Tat and Tat receptors are present in HIV-1-associated KS, which may explain the higher frequency and aggressiveness of this form compared to classical Kaposi's sarcoma where only bFGF is present.

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Authors and Affiliations

  1. Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Barbara Ensoli, Rita Gendelman, Valeria Fiorelli, Sandra Colombini, Hsiao-Kuey Chang & Robert C. Gallo

  2. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Mark Raffeld

  3. Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    John N. Brady

  4. Advanced BioScience Laboratories Inc., Kensington, Maryland, 20895, USA

    Phillip Markham

  5. Henry M. Jackson Foundation, Rockville, Maryland, 20850, USA

    Aurelio Cafaro

Authors
  1. Barbara Ensoli
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  2. Rita Gendelman
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  3. Phillip Markham
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  4. Valeria Fiorelli
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  5. Sandra Colombini
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  6. Mark Raffeld
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  7. Aurelio Cafaro
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  8. Hsiao-Kuey Chang
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  9. John N. Brady
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  10. Robert C. Gallo
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Ensoli, B., Gendelman, R., Markham, P. et al. Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma. Nature 371, 674–680 (1994). https://doi.org/10.1038/371674a0

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  • DOI: https://doi.org/10.1038/371674a0

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