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The ancient regulatory-protein family of WD-repeat proteins

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An Erratum to this article was published on 27 October 1994

WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular functions, such as cell division, cell-fate determination, gene transcription, transmembrane signalling, mRNA modification and vesicle fusion. Here we define the common features of the repeating units, and criteria for grouping such proteins into functional subfamilies.

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References

  1. Fong, H. K. W. et al. Proc. natn. Acad. Sci. U.S.A. 83, 2162–2166 (1986).

    Article  ADS  CAS  Google Scholar 

  2. Duronio, R. J., Gordon, J. L. & Boguski, M. S. Proteins 13, 41–56 (1992).

    Article  CAS  Google Scholar 

  3. van der Voorn, L. & Ploegh, H. L. FEBS Lett. 307, 131–134 (1992).

    Article  CAS  Google Scholar 

  4. Neer, E. J., Schmidt, C. J. & Smith, T. F. Nature Genet. 4, 3–4 (1993).

    Article  Google Scholar 

  5. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. J. molec. Biol. 215, 403–410 (1990).

    Article  CAS  Google Scholar 

  6. Whiteway, M. et al. Cell 56, 467–477 (1989).

    Article  CAS  Google Scholar 

  7. van der Voorn, L., Gebbink, M., Plasterk, R. H. A. & Ploegh, H. I. J. molec. Biol. 213, 17–26 (1990).

    Article  CAS  Google Scholar 

  8. Ryba, N. J., Pottinger, J. D. D., Keen, J. N. & Findlay, J. B. C. Biochem. J. 273, 225–228 (1991).

    Article  CAS  Google Scholar 

  9. Yarfitz, S., Niemi, G. A., McConnell, J. L., Fitch, C. L. & Hurley, J. B. Neuron 7, 429–438 (1991).

    Article  CAS  Google Scholar 

  10. Levine, M. A., Smallwood, P. M., Moen, P. T. Jr, Helman, L. J. & Ahn, T. G. Proc. natn. Acad. Sci. U.S.A. 87, 2329–2333 (1990).

    Article  ADS  CAS  Google Scholar 

  11. von Weizsäcker, E., Strathmann, M. P. & Simon, M. I. Biochem. biophys. Res. Commun. 183, 350–356 (1992).

    Article  Google Scholar 

  12. Gao, B., Gilman, A. G. & Robishaw, J. D. Proc. natn. Acad. Sci. U.S.A. 84, 6122–6125 (1987).

    Article  ADS  CAS  Google Scholar 

  13. Lilly, P., Wu, L., Welker, D. L. & Devreotes, P. N. Genes Dev. 7, 986–996 (1993).

    Article  CAS  Google Scholar 

  14. Artavanis-Tsakonas, S., Delidakis, C. & Fehon, F. G. A. Rev. Cell Biol. 7, 427–452 (1991).

    Article  CAS  Google Scholar 

  15. Schmidt, C. J. & Sladek, T. E. J. biol. Chem. 268, 25681–25686 (1993).

    CAS  PubMed  Google Scholar 

  16. Shenolikar, S. & Nairn, A. C. Adv. Second messeng. phosphopr. Res. 25, 1–121 (1991).

    Google Scholar 

  17. Healy, A. M. et al. Molec. Cell Biol. 11, 5767–5780 (1991).

    Article  CAS  Google Scholar 

  18. Mayer-Jaekel, R. E. et al. Cell 72, 621–633 (1993).

    Article  CAS  Google Scholar 

  19. Mayer, V. E. et al. Biochemistry 30, 3589–3597 (1991).

    Article  CAS  Google Scholar 

  20. Ron, D. et al. Proc. natn. Acad. Sci. U.S.A. 91, 839–843 (1994).

    Article  ADS  CAS  Google Scholar 

  21. Schloss, J. A. Molec. gen. Genet. 221, 443–452 (1990).

    Article  CAS  Google Scholar 

  22. Guillemot, F., Billault, A. & Auffray, C. Proc. natn. Acad. Sci. U.S.A. 86, 4594–4598 (1989).

    Article  ADS  CAS  Google Scholar 

  23. Ishida, S., Yohsuke, T. & Nagata, T. Proc. natn. Acad. Sci. U.S.A. 90, 11152–11156 (1993).

    Article  ADS  CAS  Google Scholar 

  24. Qian, Y-W. et al. Nature 364, 648–652 (1993).

    Article  ADS  CAS  Google Scholar 

  25. Ruggieri, R. et al. Proc. natn. Acad. Sci. U.S.A. 86, 8778–8782 (1989).

    Article  ADS  CAS  Google Scholar 

  26. Pryer, N. K., Salama, N. R., Schekman, R. & Kaiser, C. A. J. Cell Biol. 120, 865–875 (1993).

    Article  CAS  Google Scholar 

  27. Clark, M. A. et al. Proc. natn. Acad. Sci. U.S.A. 88, 5418–5422 (1991).

    Article  ADS  CAS  Google Scholar 

  28. Bubis, J. & Khorana, H. G. J. biol. Chem. 265, 12995–12999 (1990).

    CAS  PubMed  Google Scholar 

  29. Schmidt, C. J. & Neer, E. J. J. biol. Chem. 266, 4538–4544 (1991).

    CAS  PubMed  Google Scholar 

  30. Disatnik, M-H., Hernandez-Sotomayor, T., Jones, G., Carpenter, G. & Mochly-Rosen, D. Proc. natn. Acad. Sci. U.S.A. 91, 559–563 (1994).

    Article  ADS  CAS  Google Scholar 

  31. Clapham, D. E. & Neer, E. J. Nature 365, 403–406 (1993).

    Article  ADS  CAS  Google Scholar 

  32. Yi, F., Denker, B. D., Neer, E. J. J. biol. Chem. 266, 3900–3906 (1991).

    CAS  Google Scholar 

  33. Pitcher, J. et al. Science 257, 1264–1267 (1992).

    Article  ADS  CAS  Google Scholar 

  34. Touhara, K., Inglese, J., Pitcher, J. A., Shaw, G. & Lefkowitz, X. J. Biol. Chem. 269, 10217–10220 (1994).

    CAS  PubMed  Google Scholar 

  35. Banroques, J. & Abelson, J. Molec. cell. Biol. 9, 3710–3719 (1989).

    Article  CAS  Google Scholar 

  36. Petersen-Bjørn, S., Soltyk, A., Geggs, J. D. & Friesen, J. D. Molec. cell. Biol. 9, 3698–3709 (1989).

    Article  Google Scholar 

  37. Bordonné, R., Banroques, J., Abelson, J. & Guthrie, C. Genes Dev. 4, 1185–1196 (1990).

    Article  Google Scholar 

  38. Takagaki, Y. & Manley, J. L. J. biol. Chem. 267, 23471–23474 (1992).

    CAS  PubMed  Google Scholar 

  39. Dynlacht, B. D., Weinzierl, O. J., Admon, A. & Tijan, R. Nature 363, 176–179 (1993).

    Article  ADS  CAS  Google Scholar 

  40. Koleske, A. J. & Young, R. A. Nature 368, 466–469 (1994).

    Article  ADS  CAS  Google Scholar 

  41. Keleher, C. A., Redd, M. J., Schultz, J., Carlson, M. & Johnson, A. D. Cell 68, 709–719 (1992).

    Article  CAS  Google Scholar 

  42. Williams, F. E., Varanasi, U. & Trumbly, R. J. Molec. Cell. Biol. 11, 3307–3316 (1991).

    Article  CAS  Google Scholar 

  43. Stenbeck, G. et al. EMBO J. 12, 2841–2845 (1993).

    Article  CAS  Google Scholar 

  44. Harrison-Lavoie, K. J. et al. EMBO J. 12, 2847–2853 (1993).

    Article  CAS  Google Scholar 

  45. Sneath, P. H. A. & Sokal, R. R. Numerical Taxonomy (Freedman, San Francisco, 1973).

    MATH  Google Scholar 

  46. Swofford, D. L. PAUP User's Guide (Illinois Natural History Survey Press, Champaign, 1985).

    Google Scholar 

  47. Knoll, A. H. Science 256, 622–627 (1992).

    Article  ADS  CAS  Google Scholar 

  48. Morris, S. C. Nature 361, 219–225 (1993).

    Article  ADS  Google Scholar 

  49. Spevak, W., Keiper, B. D., Stratowa, C. & Castanon, M. J. Molec. cell. Biol. 13, 4953–4956 (1993).

    Article  CAS  Google Scholar 

  50. Smith, R. F. & Smith, T. F. Proc. natn. Acad. Sci. U.S.A. 87, 118–122 (1990).

    Article  ADS  CAS  Google Scholar 

  51. Reiner, O. et al. Nature 364, 717–721 (1993).

    Article  ADS  CAS  Google Scholar 

  52. Hattori, M., Adachi, H., Tsujimoto, M., Arai, H. & Inoue, K. Nature 370, 216–218 (1994).

    Article  ADS  CAS  Google Scholar 

  53. Icho, T. & Wickner, R. B. J. biol. Chem. 263, 1467–1475 (1988).

    CAS  PubMed  Google Scholar 

  54. Deng, X-W. et al. Cell 71, 791–801 (1992).

    Article  CAS  Google Scholar 

  55. Stifani, S., Blaumueller, C. M., Redhead, N. J., Hill, R. E. & Artavanis-Tsakonas, S. Nature Genet. 2, 119–127 (1992).

    Article  CAS  Google Scholar 

  56. Sherwood, P. W., Tsang, S. V.-M. & Osley, M. A. Molec. cell. Biol. 13, 28–38 (1993).

    Article  CAS  Google Scholar 

  57. Choi, W.-J., Clark, M. W., Chen, J. X. & Jong, A. Y. Biochem. biophys. Res. Commun. 172, 1324–1330 (1990).

    Article  CAS  Google Scholar 

  58. Sethi, N., Monteagudo, M. C., Koshland, D., Hogan, E. & Burke, D. J. Molec. cell. Biol. 11, 5592–5602 (1991).

    Article  CAS  Google Scholar 

  59. de Hostos, E. L. et al. J. Cell Biol. 120, 163–173 (1993).

    Article  CAS  Google Scholar 

  60. Shaw, D. R., Richter, H., Giorda, R., Ohmachi, T. & Ennis, H. L. Molec. gen. Genet. 218, 453–459 (1989).

    Article  CAS  Google Scholar 

  61. Bergsagel, P. L., Timblin, C. R., Eckhardt, L., Laskov, R. & Kuehl, W. M. Oncogene 17, 2059–2064 (1992).

    Google Scholar 

  62. Oliver, S. G. et al. Nature 357, 38–46 (1992).

    Article  ADS  CAS  Google Scholar 

  63. Goebl, M. & Yanagida, M. Trends biochem. Sci. 16, 173–177 (1991).

    Article  CAS  Google Scholar 

  64. Martinez-Oyanedel, J., Choe, H. W., Heinemann, U. & Saenger, W. J. molec. Biol. 222, 335 (1991).

    Article  CAS  Google Scholar 

  65. Weinstein, J., Jacobsen, F. W., Hsu-Chen, J., Wu, T. & Baum, L. G. Molec. cell. Biol. 14, 3350–3363 (1994).

    Article  CAS  Google Scholar 

  66. Kumar, S., Matsuzaki, T., Yoshida, Y. & Noda, M. J. biol. Chem. 269, 11318–11326 (1994).

    CAS  PubMed  Google Scholar 

  67. Herman, P. K., Stack, J. H., Demodena, J. A. & Emr, S. O. Cell 64, 425–437 (1991).

    Article  CAS  Google Scholar 

  68. Jansen, R., Tollervey, D. & Hurt, E. C. EMBO J. 12, 2549–2558 (1993).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School,

    Eva J. Neer & Carl J. Schmidt

  2. the Department of Pharmacology and Biomolecular Engineering Research Centre, Boston University, Boston, Massachusetts, 02215, USA

    Raman Nambudripad & Temple F. Smith

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  1. Eva J. Neer
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Neer, E., Schmidt, C., Nambudripad, R. et al. The ancient regulatory-protein family of WD-repeat proteins. Nature 371, 297–300 (1994). https://doi.org/10.1038/371297a0

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