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An early haematopoietic defect in mice lacking the transcription factor GATA-2

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Abstract

Blood cell development relies on the expansion and maintenance of haematopoietic stem and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we demonstrate that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type. We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells.

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Author notes

  1. Stuart H. Orkin: To whom correspondence should be addressed

Authors and Affiliations

  1. Division of Hematology-Oncology, Children's Hospital and Dana Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Fong-Ying Tsai, Mitchell Weiss, Margery Rosenblatt & Stuart H. Orkin

  2. Howard Hughes Medical Institute, Children's Hospital, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA

    Fong-Ying Tsai, Frederick W. Alt & Stuart H. Orkin

  3. Department of Genetics, Harvard Medical School and Center for Blood Research, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA

    Jianzhou Chen & Frederick W. Alt

  4. Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA

    Frank C. Kuo

  5. The National Jewish Center, Denver, Colorado, 80206, USA

    Gordon Keller

Authors
  1. Fong-Ying Tsai
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  2. Gordon Keller
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  3. Frank C. Kuo
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  4. Mitchell Weiss
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  5. Jianzhou Chen
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  6. Margery Rosenblatt
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  7. Frederick W. Alt
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  8. Stuart H. Orkin
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Tsai, FY., Keller, G., Kuo, F. et al. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371, 221–226 (1994). https://doi.org/10.1038/371221a0

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  • DOI: https://doi.org/10.1038/371221a0

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