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c-Mpl ligand is a humoral regulator of megakaryocytopoiesis

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Abstract

MEGAKARYOCYTOPOIESIS is the cellular developmental process that leads to platelet production. At least two humoral growth factors may be necessary for megakaryocyte proliferation and maturation. One is a megakaryocyte-colony stimulating factor (MK-CSF) which induces the proliferation and differentiation of megakaryocyte progenitors1,2, and the second, thrombopoietin, is a megakaryocyte maturation factor3. Neither of these factors has been fully characterized. The proto-oncogene c-mpl, an orphan member of the haematopoietin receptor family4–6, is specifically involved in megakaryocyte regulation7. Here we present evidence that the c-mpl-encoded receptor binds a ligand (c-Mpl ligand) which is a humoral factor implicated in platelet homeostasis. Our results suggest that c-Mpl ligand, thrombopoietin and MK-CSF might be the same molecule.

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Authors and Affiliations

  1. INSERM U362, Institut Gustave Roussy, 94805, Villejuif, France

    Françoise Wendling, Najet Debili, Monique Titeux, Nassia Methia & William Vainchenker

  2. Immunex Corporation, 51 University Street, Seattle, Washington, 98101, USA

    Eugene Maraskovsky, Christina Florindo, Mark Teepe & David Cosman

  3. INSERM U91, Hôpital Henri Mondor, 94010, Créteil, France

    Janine Breton-Gorius

Authors
  1. Françoise Wendling
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  2. Eugene Maraskovsky
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  3. Najet Debili
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  4. Christina Florindo
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  5. Mark Teepe
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  6. Monique Titeux
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  7. Nassia Methia
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  8. Janine Breton-Gorius
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  9. David Cosman
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  10. William Vainchenker
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Wendling, F., Maraskovsky, E., Debili, N. et al. c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369, 571–574 (1994). https://doi.org/10.1038/369571a0

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  • DOI: https://doi.org/10.1038/369571a0

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