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Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

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Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.

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Author information

Author notes

  1. Karl J. Oles: Hematology Research Section, Mayo Clinic, Rochester, Minnesota 55905, USA

  2. Lawrence A. Solberg: Division Hematology-Oncology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA

  3. Dan L. Eaton: To whom correspondence should be addressed.

Authors and Affiliations

  1. The Departments of Molecular Biology, Cardiovascular Research and Protein Chemistry, Genentech, 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA

    Frederic J. de Sauvage, Philip E. Hass, Susan D. Spencer, Beth E. Malloy, Austin L. Gurney, Steven A. Spencer, Walter C. Darbonne, William J. Henzel, Suzy C. Wong, Wun-Jing Kuang, Karl J. Oles, Bruce Hultgren, Lawrence A. Solberg Jr, David V. Goeddel & Dan L. Eaton

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  1. Frederic J. de Sauvage
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  2. Philip E. Hass
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  3. Susan D. Spencer
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  4. Beth E. Malloy
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  5. Austin L. Gurney
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  6. Steven A. Spencer
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  7. Walter C. Darbonne
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  8. William J. Henzel
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  9. Suzy C. Wong
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  10. Wun-Jing Kuang
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  11. Karl J. Oles
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  12. Bruce Hultgren
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  13. Lawrence A. Solberg Jr
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  14. David V. Goeddel
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  15. Dan L. Eaton
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de Sauvage, F., Hass, P., Spencer, S. et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369, 533–538 (1994). https://doi.org/10.1038/369533a0

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  • DOI: https://doi.org/10.1038/369533a0

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