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Cell-cycle calcium transients driven by cyclic changes in inositol trisphosphate levels

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Abstract

TRANSIENT changes in intracellular calcium ([Ca2+]i) have been shown to punctuate the cell cycle in various types of cells in culture1–5 and in early embryos6–12. The [Ca2+]i transients are correlated with cell-cycle events: pronuclear migration, nuclear envelope breakdown, the metaphase–anaphase transition of mitosis, and cytokinesis. Mitotic events can be induced by injecting calcium and prevented by injecting calcium chelators into the sea urchin embryo10,13. Cell-cycle calcium transients differ from the transients linked to membrane signal transduction pathways: they are generated by an endogenous mechanism, not by plasma membrane receptor complexes, and their trigger is unknown. We report here that the phosphoinositide messenger system oscillates during the early embryonic cell cycle in the sea urchin, leading to cyclic increases in inositol trisphosphate that trigger cell-cycle [Ca2+]i transients and mitosis by calcium release from intracellular stores.

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References

  1. Hepler, P. K. Int. Rev. Cytol. 138, 239–268 (1992).

    Article  CAS  Google Scholar 

  2. Kao, J. P. Y., Alderton, J. M., Tsien, R. Y. & Steinhardt, R. A. J. Cell Biol. 111, 183–196 (1990).

    Article  CAS  Google Scholar 

  3. Ratan, R. R., Shelanski, M. L. & Maxfield, F. R. Proc. natn. Acad. Sci. U.S.A. 83, 5136–5140 (1986).

    Article  ADS  CAS  Google Scholar 

  4. Ratan, R. R., Maxfield, F. R. & Shelanski, M. L. J. Cell Biol. 107, 993–999 (1988).

    Article  CAS  Google Scholar 

  5. Hepler, P. K. & Callahan, D. A. J. Cell Biol. 105, 2137–2143 (1987).

    Article  CAS  Google Scholar 

  6. Tombes, R. M., Simerly, C., Borisy, G. G. & Schatten, G. J. Cell Biol. 117, 799–811 (1992).

    Article  CAS  Google Scholar 

  7. Grandin, N. & Charbonneau, M. J. Cell Sci. 99, 5–11 (1991).

    CAS  PubMed  Google Scholar 

  8. Whitaker, M. J. & Patel, R. Development 108, 525–542 (1990).

    CAS  Google Scholar 

  9. Poenie, M., Alderton, J., Tsien, R. Y. & Steinhardt, R. A. Nature 315, 147–149 (1985).

    Article  ADS  CAS  Google Scholar 

  10. Steinhardt, R. A. & Alderton, J. Nature 332, 364–366 (1988).

    Article  ADS  CAS  Google Scholar 

  11. Browne, C. L., Miller, A. L., Palazzo, R. E. & Jaffe, L. F. Biol. Bull. (Woods Hole) 183, 270–371 (1992).

    Article  Google Scholar 

  12. Fluck, R. A., Miller, A. L. & Jaffe, L. F. J. Cell Biol. 115, 1259–1265 (1991).

    Article  CAS  Google Scholar 

  13. Twigg, J., Patel, R. & Whitaker, M. J. Nature 332, 366–369 (1988).

    Article  ADS  CAS  Google Scholar 

  14. Ciapa, B. & Whitaker, M. J. FEBS Lett. 195, 347–351 (1986).

    Article  CAS  Google Scholar 

  15. Murray, A. W., Solomon, M. J. & Kirschner, M. Nature 339, 280–286 (1989).

    Article  ADS  CAS  Google Scholar 

  16. Solomon, M. J., Glotzer, M., Lee, T. H., Philippe, M. & Kirschner, M. Cell 63, 113–124 (1990).

    Article  Google Scholar 

  17. Edgecombe, M., Patel, R. & Whitaker, M. J. EMBO J. 10, 3769–3775 (1991).

    Article  CAS  Google Scholar 

  18. Sluder, G., Miller, F. J., Cole, R. & Rieder, C. L. J. Cell Biol. 110, 2025–2032 (1990).

    Article  CAS  Google Scholar 

  19. Li, L. H. et al. Cancer Lett. 23, 279–288 (1984).

    Article  CAS  Google Scholar 

  20. Ciapa, B., Borg, B. & Whitaker, M. J. Development 115, 187–195 (1992).

    CAS  PubMed  Google Scholar 

  21. Galione, A. et al. Science 261, 348–352 (1993).

    Article  ADS  CAS  Google Scholar 

  22. Lee, H. C., Dargie, T. J. & Walseth, T. F. Science 261, 352–355 (1993).

    Article  ADS  CAS  Google Scholar 

  23. Han, J. K., Fukami, K. & Nuccitelli, R. J. Cell Biol. 116, 147–156 (1992).

    Article  CAS  Google Scholar 

  24. Uno, I., Fukami, K., Kato, H., Takenawa, T. & Ishikawa, T. Nature 333, 366–369 (1988).

    Article  Google Scholar 

  25. Sluder, G., Miller, F. J., Cole, R. & Rieder, C. L. J. Cell Biol. 110, 2025–2032 (1990).

    Article  CAS  Google Scholar 

  26. Gard, D. L., Hafezi, S., Zhang, T. & Doxsey, S. J. J. Cell Biol. 110, 2033–2042 (1990).

    Article  CAS  Google Scholar 

  27. Stith, B. J., Goalstone, M., Silva, S. & Jaynes, C. Molec. Biol. Cell 4, 435–443 (1993).

    Article  CAS  Google Scholar 

  28. Ciapa, B. & Maggio, K. Devl Biol. 159, 114–121 (1993).

    Article  Google Scholar 

  29. Chatfield, C. The Analysis of Time Series: An Introduction (Chapman and Hall, London, 1980).

    Book  Google Scholar 

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Author notes

  1. Brigitte Ciapa

    Present address: Groupe de Recherche sur I'interaction Gamétique, Faculté de Médicine, Av. de Vallambrose, 06107, Nice, Cedex 02, France

Authors and Affiliations

  1. Laboratoire de Physiologie Cellulaire et Comparée, Faculté des Sciences, Pare Valrose, BP 71, 06108, Nice, Cedex 02, France

    Brigitte Ciapa

  2. Unité INSERM 303, BP 3, 06230, Villefranche-Sur-Mer, France

    Danielle Pesando

  3. Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK

    Martin Wilding & Michael Whitaker

Authors
  1. Brigitte Ciapa
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  2. Danielle Pesando
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  3. Martin Wilding
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  4. Michael Whitaker
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Ciapa, B., Pesando, D., Wilding, M. et al. Cell-cycle calcium transients driven by cyclic changes in inositol trisphosphate levels. Nature 368, 875–878 (1994). https://doi.org/10.1038/368875a0

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