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Oligonucleotide probe design — a new approach

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The use of oligonucleotides for gene ampliation, as diagnostic probes or antisense-based drugs can be optimized by minimizing the possibility of nonspecific hybridization.

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References

  1. Bernstam, V. A. in Handbook of Gene Level Diagnostics in Clinical Practice 161–630 (CRC Press, Florida, 1992).

    Google Scholar 

  2. Mitsuhashi, M. et al. Nature 357, 519–520 (1992).

    Article  ADS  CAS  Google Scholar 

  3. Saiki, R. K. et al. Science 230, 1350–1354 (1985).

    Article  ADS  CAS  Google Scholar 

  4. Wu, D. Y. & Wallace, R. B. Gene 76, 245–254 (1989).

    Article  CAS  Google Scholar 

  5. Reynolds, T. J. natn. Cancer Inst. 84, 288–290 (1992).

    Article  CAS  Google Scholar 

  6. Mitsuhashi, M. & Hosokawa, T. Nippon Rinsho 52, 530–541 (1994).

    CAS  PubMed  Google Scholar 

  7. March, C. J. et al. Nature 315, 641–647 (1985).

    Article  ADS  CAS  Google Scholar 

  8. Iizuka, N., Kuge, S. & Nomoto, A. Virology 156, 64–73 (1987).

    Article  CAS  Google Scholar 

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Author notes

  1. Masato Mitsuhashi, Allan Cooper, Mieko Ogura, Tatsuo Shinagawa, Katsusuke Yano and Toshiaki Hosokawa: We thank Dennis Coad, David Hyndman, Dr Takashi Ishikawa and Dr Yasushi Ichikawa for their helpful comments. For more information, fill in reader service number 100.

Authors and Affiliations

  1. Advanced Gene Computing Technologies (AGCT), Inc., 2102 Business Center Drive, Suite 170, Irvine, California, 92715, USA

    Masato Mitsuhashi

  2. Hitachi Chemical Research Center, Inc., Irvine, CA 92715, USA

    Masato Mitsuhashi

  3. AGCT, Inc. and DigitalWord, Bellevue, Washington, 98008, USA

    Allan Cooper

  4. Hitachi Chemical Research Center, Inc.,

    Mieko Ogura

  5. the Third Department of Internal Medicine, Nagasaki University, School of Medicine, Nagasaki, Japan

    Tatsuo Shinagawa & Katsusuke Yano

  6. Hitachi Chemical Company Ltd, Tokyo, Japan

    Toshiaki Hosokawa

Authors
  1. Masato Mitsuhashi
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  2. Allan Cooper
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  3. Mieko Ogura
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  4. Tatsuo Shinagawa
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  5. Katsusuke Yano
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  6. Toshiaki Hosokawa
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Mitsuhashi, M., Cooper, A., Ogura, M. et al. Oligonucleotide probe design — a new approach. Nature 367, 759–761 (1994). https://doi.org/10.1038/367759a0

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