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Parallel genome analysis by two-dimensional DNA typing

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By two-dimensional (2-D) DNA typing a restriction enzyme digest of genomic DNA can be resolved on the basis of both size and base-pair sequence and subsequently analysed by repeat probe hybridization to reveal sequence variants at multiple genomic sites in parallel. The system has been partly automated and allows for large-scale comparative analysis of complex genomes in a cost-effective manner.

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Author notes

  1. G. J. te Meerman: For more information, fill in reader service number 100.

Authors and Affiliations

  1. Ingeny B. V., PO Box 685, 2300 AR, Leiden, The Netherlands

    E. Mullaart, G. J. de Vos, A. G. Uitterlinden & J. Vijg

  2. the Department of Medical Genetics, University of Groningen, A. Deusinglaan 4, 9713 AW, Groningen, The Netherlands

    G. J. te Meerman

Authors
  1. E. Mullaart
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  2. G. J. de Vos
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  3. G. J. te Meerman
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  4. A. G. Uitterlinden
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  5. J. Vijg
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Mullaart, E., de Vos, G., te Meerman, G. et al. Parallel genome analysis by two-dimensional DNA typing. Nature 365, 469–471 (1993). https://doi.org/10.1038/365469a0

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