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Molecular basis of the little mouse phenotype and Implications for cell type-specific growth

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Abstract

The molecular basis for the little (lit) mouse phenotype, characterized by a hypoplastic anterior pituitary gland, is the mutation of a single nucleotide that alters Asp 60 to Gly in the growth hormone releasing factor receptor. Detailed analysis of the lit mouse anterior pituitary reveals spatially distinct proliferative zones of growth hormone-producing stem cells and mature somatotrophs, each regulated by a different trophic factor. This sequential growth factor requirement for a specific cell type may exemplify a common strategy for regulating cellular proliferation in other mammalian organs.

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Eukaryotic Regulatory Biology Program, School and Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California, 92093-0648, USA

    Sheng-Cai Lin, Chijen R. Lin, Ilya Gukovsky & Michael G. Rosenfeld

  2. Department of Microbiology and Molecular Genetics, Department of Medicine and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, 90024, USA

    Aldons J. Lusis

  3. Laboratory of Neuronal Structure and Function, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California, 92037, USA

    Paul E. Sawchenko

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  1. Sheng-Cai Lin
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  2. Chijen R. Lin
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  3. Ilya Gukovsky
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  4. Aldons J. Lusis
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  5. Paul E. Sawchenko
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  6. Michael G. Rosenfeld
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Lin, SC., Lin, C., Gukovsky, I. et al. Molecular basis of the little mouse phenotype and Implications for cell type-specific growth. Nature 364, 208–213 (1993). https://doi.org/10.1038/364208a0

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  • DOI: https://doi.org/10.1038/364208a0

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