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Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41

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Abstract

DURING biosynthesis, class II molecules of the major histo-compatibility complex are associated with a nonpolymorphic protein called invariant chain, li, which facilitates folding of class II molecules and their exit from the endoplasmic reticulum1–4, interferes with their association with peptide5,6 and directs their post-Golgi transport (refs 7–9). If li blocks class II loading with endogenous antigens in the endoplasmic reticulum and/or directs class II molecules to the exogenous antigen-loading compartment, then the co-expression of li should enhance the ability of class II molecules to present exogenous antigens to T cells. But data supporting a role for li in class II-restricted antigen presentation are controversial1,10–13. Here we show that Ii can facilitate exogenous antigen presentation for a subset of antigens. Although all known functions of Ii have been ascribed to the principal form of Ii, p31, we find that in most cases antigen presentation is facilitated only by the alternatively spliced, minor form of Ii, p41.

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Authors and Affiliations

  1. Department of Molecular Genetics and Cell Biology, University of Chicago, 920 East 58th Street, Chicago, Illinois, 60637, USA

    Mary Peterson & Jim Miller

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  1. Mary Peterson
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  2. Jim Miller
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Peterson, M., Miller, J. Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41. Nature 357, 596–598 (1992). https://doi.org/10.1038/357596a0

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  • DOI: https://doi.org/10.1038/357596a0

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