Homology modelling software can predict the structure of a newly sequenced protein by incorporating conformational similarity information from related proteins for which atomic coordinates are known. Models built using structural data are more reliable than those based on sequence alignments alone.
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Lee, R. Protein model building using structural homology. Nature 356, 543–544 (1992). https://doi.org/10.1038/356543a0
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DOI: https://doi.org/10.1038/356543a0
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