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Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

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Abstract

Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has structural homology with a number of cell-surface receptors, including tumour necrosis factor receptor and nerve growth factor receptor. Mice carrying the lymphoprolifer-ation (Ipr) mutation have defects in the Fas antigen gene. The Ipr mice develop lymphadenopathy and suffer from a systemic lupus erythematosus-like autoimmune disease, indicating an important role for Fas antigen in the negative selection of autoreactive T cells in the thymus.

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Authors and Affiliations

  1. Osaka Bioscience Institute, 6-2-4 Furuedai, Suita-shi, Osaka, 565, Japan

    Rie Watanabe-Fukunaga, Neal G. Copeland, Nancy A. Jenkins & Shigekazu Nagata

  2. Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland, 21702, USA

    Camilynn I. Brannan

Authors
  1. Rie Watanabe-Fukunaga
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  2. Camilynn I. Brannan
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  3. Neal G. Copeland
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  4. Nancy A. Jenkins
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  5. Shigekazu Nagata
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Watanabe-Fukunaga, R., Brannan, C., Copeland, N. et al. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314–317 (1992). https://doi.org/10.1038/356314a0

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