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Crisscross regulation of cell-type-specific gene expression during development in B. subtilis

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Abstract

Sporulation in Bacillus subtilis is a model for how cells of one type generate other differentiated cell types. During sporulation two cellular compartments arise that differ from each other and from the progenitor cell. Differential gene expression between the two is governed by the successive appearance of four transcription factors whose activities are coordinated in crisscross fashion between the two cells.

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Authors and Affiliations

  1. Department of Cellular and Developmental Biology, The Biological Laboratories, Harvard University, Cambridge, Massachusetts, 02138, USA

    Richard Losick

  2. Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005, Paris, France

    Patrick Stragier

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  1. Richard Losick
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  2. Patrick Stragier
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Losick, R., Stragier, P. Crisscross regulation of cell-type-specific gene expression during development in B. subtilis . Nature 355, 601–604 (1992). https://doi.org/10.1038/355601a0

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