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Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor

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Abstract

During development of the Drosophila retina, the R8 photoreceptor neuron induces a neighbouring cell to assume an R7 cell fate. Genetic data suggest that the induction is mediated by two transmem-brane proteins encoded by bride of sevenless and sevenless. A direct interaction between these two proteins was demonstrated by the heterotypic aggregation of cell lines expressing them. In the developing eye the sevenless-dependent internalization of bride of sevenless by the R7 precursor cell provides evidence for a direct interaction between these two proteins in vivo.

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Authors and Affiliations

  1. Department of Biological Chemistry, The School of Medicine and The Molecular Biology Institute, University of California, Los Angeles, California, 90024-1737, USA

    Helmut Krämer, Ross L. Cagan & S. Lawrence Zipursky

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  1. Helmut Krämer
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  2. Ross L. Cagan
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  3. S. Lawrence Zipursky
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Krämer, H., Cagan, R. & Zipursky, S. Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor. Nature 352, 207–212 (1991). https://doi.org/10.1038/352207a0

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