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Gene regulation

Cycling silence

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The cell-division cycle involves careful timing: cell-cycle genes must be switched on only when needed. The retinoblastoma protein controls one set of these genes, and one way it does this is most unusual.

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Figure 1: Silencing in heterochromatin, a compact form of DNA, by the HP1 and SUV39H1 proteins.
Figure 2: Silencing during the cell cycle.

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  1. Center of Molecular Biology (ZMBH), University of Heidelberg, Im Neuenheimer Feld 282, Heidelberg, 69120, Germany

    Leonie Ringrose & Renato Paro

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  1. Leonie Ringrose
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  2. Renato Paro
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Correspondence to Renato Paro.

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Ringrose, L., Paro, R. Cycling silence. Nature 412, 493–494 (2001). https://doi.org/10.1038/35087692

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