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Natural selection and resistance to HIV

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A genotype that lowers susceptibility to HIV extends survival at a time of peak fertility.

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Figure 1: Expected lifetime reproduction of carriers of CCR5 mutations relative to the normal CCR5 genotype as a function of the period between HIV infection and the onset of AIDS.

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Authors and Affiliations

  1. Department of Integrative Biology, University of California, Berkeley, 94720, California, USA

    Paul Schliekelman, Chad Garner & Montgomery Slatkin

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  1. Paul Schliekelman
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  2. Chad Garner
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  3. Montgomery Slatkin
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Correspondence to Paul Schliekelman.

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Schliekelman, P., Garner, C. & Slatkin, M. Natural selection and resistance to HIV. Nature 411, 545–546 (2001). https://doi.org/10.1038/35079176

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